ArticleBiomedical engineering online2026
Investigating the early diagnostic value of popliteal artery wall shear stress in lower extremity arterial disease in type 2 diabetes patients using color Doppler ultrasound combined with WSS quantitative analysis.
Article in Biomedical engineering online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe global increase in type 2 diabetes mellitus (T2DM) has contributed to a growing burden of lower extremity arterial disease (LEAD), often detected at advanced stages due to limitations in current diagnostic methods. While the ankle-brachial index (ABI) is widely used, it provides no structural information; advanced imaging such as DSA, CTA, or MRA involves radiation, contrast agents, or high cost. Color Doppler ultrasound (DUS) offers a non-invasive and economical alternative for hemodynamic assessment. This study proposes an integrated approach combining DUS with custom MATLAB-based software to quantify wall shear stress (WSS) in the popliteal artery, aiming to establish WSS as a potential early marker of LEAD in T2DM patients.
resultsIn a study comparing T2DM patients to controls, T2DM groups showed significantly altered blood pressure, blood lipids, and blood viscosity, along with reduced WSS values, indicating advanced arterial damage. Specifically, WSS was lower in T2DM groups with normal and thickening IMT and those with plaque formation compared to controls. The optimal WSS cutoff for predicting LEAD was 1.82 dyne/cm
conclusionsNon-invasive WSS measurement using DUS provides a valuable diagnostic tool for early LEAD detection in T2DM patients. Reduced WSS in the popliteal artery is a predictive marker of disease onset, offering potential for earlier intervention and better management of LEAD, ultimately improving patient outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.