Evidence map›Paper›PMID 41749296›Full record

ArticleBiology of sex differences2026

SASdb: a comprehensive database for sex-biased alternative splicing profiles in human tissues.

Xi Chen, Yueqi Lu, You Duan, Yongfeng Bai, Weidong Ye, Sijia Chen, Hang Zhou, Heng Xu, Le Xu, Cheng Guo

Abstract read
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In one paragraph

Article in Biology of sex differences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xi Chen *Department of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
Yueqi Lu *Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, 324000, China.
You Duan *The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University, School of Life Sciences of Fudan University, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Yongfeng BaiDepartment of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
Weidong YeDepartment of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
Sijia ChenDepartment of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
Hang ZhouCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Heng XuDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610000, China.
Le XuZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310058, China.
Cheng GuoDepartment of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China. chguo@wmu.edu.cn.

Funding

Quzhou technology projects 2025K058Quzhou technology projects 2025K063the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2024KY891the Technology Project of Zhejiang Provincial Disease Control and Prevention Administration 2025JK009Zhejiang Provincial Natural Science Foundation LQZQN25H250003
6 · The paper itself

Abstract

Alternative splicing (AS) significantly enhances transcriptomic diversity, and its dysregulation is implicated in numerous human diseases. However, no public database systematically compiles sex-related AS events across human tissues. We developed SASdb ( http://www.gdbioinfo.top/sasdb ), a comprehensive database contains 2,951,059 AS events and 46,418 sex-biased alternative splicing (SAS) events, covering 22 human tissues. SASdb reveals extensive sex-specific splicing patterns, offering new insights into molecular sex differences. A case study on NSCLC-specific SAS events, absent in healthy tissues, highlights their enrichment in cancer-related pathways like autophagy, GPI-anchor biosynthesis, and AMPK/mTOR signaling. SASdb's intuitive visualization supports research in sex biology and precision medicine.

Indexed as

Alternative SplicingDatabases, GeneticSex CharacteristicsTranscriptomeBiocurationFemaleHumansMaleAlternative splicingDatabaseHuman tissuesPrecision medicineSex differences

Identifiers

PMID41749296
PMCPMC13041291

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.