Evidence map›Paper›PMID 41749487›Full record

ArticleMolecular nutrition & food research2026

Epigenetic Regulation of the BDNF Gene by Molybdenum in 9 to 11-Year-Old Children: A Targeted Gene DNA Methylation Study.

Margaret A Voss, Stefanie R Pilkay, Dustin T Hill, Lynn S Brann, Kestutis Bendinskas, Patrick J Parsons, Christopher D Palmer, Brooks B Gump

Abstract read
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In one paragraph

Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Margaret A VossFalk College of Sport and Human Dynamics, Syracuse University Department of Nutrition and Food Studies, Syracuse, New York, USA.ORCID 0000-0002-7969-4871
Stefanie R PilkaySchool of Social Work, Syracuse University, Syracuse, New York, USA.ORCID 0000-0001-5679-2420
Dustin T HillMaxwell School of Citizenship and Public Affairs, Syracuse University Public Health Department, Syracuse, New York, USA.ORCID 0000-0002-4073-6093
Lynn S BrannFalk College of Sport and Human Dynamics, Syracuse University Department of Nutrition and Food Studies, Syracuse, New York, USA.ORCID 0000-0002-7326-6219
Kestutis BendinskasDepartment of Chemistry, State University of New York College at Oswego, Oswego, New York, USA.ORCID 0000-0002-0275-520X
Patrick J ParsonsLaboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0001-9133-875X
Christopher D PalmerLaboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-6637-991X
Brooks B GumpMaxwell School of Citizenship and Public Affairs, Syracuse University Public Health Department, Syracuse, New York, USA.ORCID 0000-0001-5906-6651

Funding

Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR)U2CES026542 · NIEHS · WADSWORTH CENTER · 2023 to 2025
$2.0M
NIEHS NIH HHS R01 ES023252NIEHS NIH HHS U2C ES026542
6 · The paper itself

Abstract

While essential trace minerals are known to influence DNA methylation (DNAm), molybdenum's (Mo) role in epigenetic regulation remains largely unexplored. This study examined associations between Mo status and DNAm of the brain-derived neurotrophic factor (BDNF) gene, a critical regulator of neurogenesis, in children aged 9-11 years, focusing on 107 CpG sites across BDNF and its antisense transcript (BDNF-AS).BDNF and BDNF-AS methylation was analyzed in blood samples from 72 children randomly selected from a cohort of 292 participants. Dietary Mo intake was estimated from food records, and creatinine-adjusted urinary Mo levels were quantified. Higher urinary molybdenum was significantly associated with decreased methylation at five BDNF 5'UTR sites (p<.05) and increased methylation of BDNF-AS (p =  .0001), consistent with enhanced BDNF transcriptional activity. African American children exhibited lower urinary Mo excretion than European American children, suggesting greater retention, and showed cortisol-associated increases in BDNF methylation not observed in European American children.These findings demonstrate associations between molybdenum status and DNA methylation patterns at the BDNF locus in children. While functional validation through BDNF protein measurement is needed, results suggest molybdenum may influence neurotrophin gene regulation through epigenetic mechanisms, highlighting the importance of trace mineral nutrition during neurodevelopment.

Indexed as

Brain-Derived Neurotrophic FactorDNA MethylationEpigenesis, GeneticMolybdenumChildCpG IslandsFemaleHumansMaleBDNF protein, humanBrain-Derived Neurotrophic FactorMolybdenumbdnfepigenetic regulationmolybdenumneurodevelopment

Identifiers

PMID41749487
PMCPMC12946595

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.