ArticleChildren (Basel, Switzerland)2026
Sonographic Brain Volume Growth Trajectories in VLBW and Clinical Determinants-Data from the NeoNEVS Project.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Altered corpus callosum development and corpus callosum-cerebellar spatial relationships in preterm infants at term-equivalent age.Quantitative imaging in medicine and surgery · 2026Article
- Neurodevelopmental Outcome in Very Low Birth Weight Preterm Infants: An Exploratory Multivariable Analysis Including Sonographic Brain Volume Trajectories-Data from the NeoNEVS Project.Children (Basel, Switzerland) · 2026Article
- The relationship between sonographically assessed volumetric brain development in VLBW preterm infants and neurodevelopmental outcome at 2 years of age-data from the NeoNEVS project.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVery Low Birth Weight preterm infants are at elevated risk for disrupted brain growth and later neurodevelopmental impairment. Bedside-accessible tools for monitoring cerebral development remain limited.
methodsIn this retrospective pilot cohort study, 153 Very Low Birth Weight infants (<32 weeks gestational age and/or <1500 g) from two Level III Neonatal Intensive Care Units underwent serial cranial ultrasound assessments. Total brain volume was estimated using an ellipsoid formula derived from standardized imaging planes. Growth trajectories were analysed via linear mixed-effects modelling. Associations with clinical predictors-including invasive ventilation, sepsis, and somatic growth-were evaluated.
resultsA total of 976 brain volume measurements were collected. Median cerebral volume increased from 164 cm
conclusionsSonographic brain volumetry is a feasible and non-invasive method for tracking cerebral development in Very Low Birth Weight infants. These findings confirm significant associations between cerebral growth and head growth and identify prolonged invasive ventilation as a risk factor for impaired cerebral development.
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