ReviewCancers2026
Exploring the Role of Advanced MRI in Understanding Glioblastoma Biology: A Scoping Review.
Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong adult primary brain tumours, glioblastoma (GBM) carries the worst prognosis. Magnetic resonance imaging (MRI) serves to diagnose and guide treatment, despite recognised constraints. Advanced MRI techniques-magnetic resonance spectroscopy (MRS), amide proton transfer-weighted imaging (APTw), diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), and quantitative susceptibility mapping (QSM)-reveal GBM characteristics that conventional sequences cannot detect. The 2021 World Health Organization reclassification disrupted established imaging-biology relationships, necessitating isocitrate dehydrogenase wildtype (IDHwt) GBM-specific evidence integration. This review synthesises biological insights provided by advanced MRI in preoperative IDHwt GBM.
methodsWe conducted a scoping review following the PRISMA-ScR framework, querying five databases (PubMed, Scopus, Cochrane, EBSCO, and Embase) to identify literature using advanced MRI to investigate biological correlates in IDHwt GBM.
resultsMRS ratios were associated with tumour presence and Ki-67 expression. APTw demonstrated robust associations with cellularity but failed to predict O6-methylguanine-DNA methyltransferase promoter (MGMTp) methylation. DWI exhibited variable utility; certain metrics linked to cellularity, while apparent diffusion coefficient values were inconsistent but useful for predicting MGMTp status, telomerase reverse transcriptase promoter mutations, and CD163+ macrophage infiltration. PWI showed relationships with cellularity, micro-vessel area, and MGMTp status. QSM features correlated with Ki-67, ferritin, and immune markers.
conclusionsAdvanced MRI demonstrates potential for biological stratification of GBM, though protocol variability and limited reproducibility hinder clinical translation. Standardised pipelines and prospective multicentre validation must precede clinical adoption, before these techniques can benefit patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.