ArticleBiomolecules2026
TRIC-A Loss Sensitizes the Heart to β-Adrenergic Stress and Drives Cardiomyocyte Death and Fibrosis.
Ki Ho Park, Daiju Yamazaki, Xinyu Zhou, Shinji Komazaki, Chengzhu Zhao, Miyuki Nishi, Jingsong Zhou, Hiroshi Takeshima, Jianjie Ma
Abstract read
In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Ki Ho ParkDepartment of Surgery, Division of Surgical Sciences, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0002-6193-9826 Daiju YamazakiResearch Unit for Physiological Chemistry, the Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8502, Japan.
Xinyu ZhouDepartment of Surgery, Division of Surgical Sciences, University of Virginia, Charlottesville, VA 22903, USA.
Shinji KomazakiDepartment of Anatomy, Saitama Medical University, Saitama 350-0495, Japan.
Chengzhu ZhaoDepartment of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0001-7957-5381 Miyuki NishiDepartment of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Jingsong ZhouDepartment of Kinesiology, University of Texas at Arlington, Arlington, TX 76010, USA.
Hiroshi TakeshimaResearch Unit for Physiological Chemistry, the Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8502, Japan.
Jianjie MaDepartment of Surgery, Division of Surgical Sciences, University of Virginia, Charlottesville, VA 22903, USA.
Funding
Japan Society for the Promotion of Science JP22790209Japan Society for the Promotion of Science JP23136506Japan Society for the Promotion of Science JP24659131Japan Society for the Promotion of Science JP24680041National Institute of Health R01AG071676National Institute of Health R01AG072430National Institute of Health R01EY036243National Institute of Health R01HL138570National Institute of Health R01HL157215National Institute of Health R01NS129219
6 · The paper itselfAbstract
Trimeric intracellular cation channel A (TRIC-A) provides counter-ion support for sarcoplasmic reticulum (SR) Ca
Indexed as
Myocytes, CardiacAdrenergic beta-AgonistsAnimalsCalciumCalcium ChannelsCell DeathCyclic AMP-Dependent Protein KinasesFibrosisIsoproterenolMiceMice, KnockoutMitochondrial ProteinsPhospholambanReceptors, Adrenergic, betaRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumAdrenergic beta-AgonistsCalciumCalcium ChannelsCyclic AMP-Dependent Protein KinasesIsoproterenolMcu protein, mouseMitochondrial ProteinsPhospholambanReceptors, Adrenergic, betaryanodine receptor 2. mouseRyanodine Receptor Calcium Release Channelcalcium handlingcardiac fibrosiscardiomyocyte necrosismitochondrial Ca2+ overloadryanodine receptor 2sarcoplasmic reticulumTRIC-Aβ-adrenergic stimulation
Identifiers
PMID41750252
PMCPMC12937667
What Socratic holds
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