ArticleBiomolecules2026
Phytochemicals Possess Selective Chemopreventive Mechanisms That Safeguard Human Cells from Oxidative Toxicity.
Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oxidative stress from environmental pollutants is linked to chronic degenerative diseases. Research indicates that specific phytochemicals in our diets can reduce and mitigate the harmful effects of pro-oxidant insults on health. However, limited randomized clinical trials show the protective effects of these compounds. This lack of in vivo evidence is partly due to the low bioavailability of these compounds, which can obscure their actual benefits. The present work investigates whether selected dietary phytochemicals are equally effective in activating cellular defense against oxidative stress at low doses. In a previous study, we found that Curcumin (Curc) at a concentration of 1 μM protected human myeloid cells from cytotoxicity induced by pro-oxidant species by activating the expression of Nrf2/ARE-dependent transcripts, including NADPH: quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1). Now, we aim to extend our observation to other natural activators of the Nrf2 pathway, such as Sulforaphane (SFN) and three structurally related molecules belonging to the flavonoid family: Quercetin (Q), Catechin (C), and Fisetin (F). These compounds were applied at low concentrations (1 μM) to assess their antioxidant activity against H
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