Evidence map›Paper›PMID 41750349›Full record

ArticleBiomolecules2026

Mitigation of Ischemia/Reperfusion-Induced Acute Kidney Injury by Canagliflozin Is Associated with Altered Mitochondrial Dynamics and Reduced Proliferation in Swine.

Zaria K Killingsworth, Malikeya Chaudhary, John A Mares, Hengying Ellery, Cassie J Rowe, Ian J Stewart, Patrick F Walker, David M Burmeister

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zaria K KillingsworthBattlefield Shock and Organ Support Laboratory, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-8455-8532
Malikeya ChaudharyBattlefield Shock and Organ Support Laboratory, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
John A MaresBattlefield Shock and Organ Support Laboratory, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Hengying ElleryDepartment of Laboratory Animal Resources, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Cassie J RoweDepartment of Surgery, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0001-8067-8409
Ian J StewartBattlefield Shock and Organ Support Laboratory, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Patrick F WalkerBattlefield Shock and Organ Support Laboratory, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
David M BurmeisterBattlefield Shock and Organ Support Laboratory, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-1256-0158

Funding

Defense Health Agency HU00011920072
6 · The paper itself

Abstract

Increasing evidence implicates mitochondrial/cellular dynamics in ischemia reperfusion (I/R)-induced acute kidney injury (AKI). Sodium-glucose-co-transporter-2 inhibitors (SGLT2is, e.g., canagliflozin, CG) have been shown to mitigate I/R-induced AKI. Here, we hypothesized that CG-improved AKI was associated with altered mitochondrial dynamics and apoptosis in a previously established swine model. CG (300 mg, PO) significantly increased pro-apoptotic genes

Indexed as

Acute Kidney InjuryCanagliflozinMitochondrial DynamicsReperfusion InjuryAnimalsApoptosisCell ProliferationMitochondriaSwineCanagliflozinacute kidney injury (AKI)apoptosisCanagliflozin (CG)cell proliferationhemorrhagic shockischemia reperfusion injury (I/R)mitochondrial dynamicsREBOASGLT2 inhibitorswine

Identifiers

PMID41750349
PMCPMC12938736

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.