Cyclo-(His-Phe) Complexes with Copper and Zinc Nanoparticles Have Antimicrobial Properties and Targeted Anticancer Potential Against Osteosarcoma Cells.

Chrysanthi Pinelopi Apostolidou, Georgios Charalambidis, Aikaterini Gialouri, Maria Chatzinikolaidou, Anna Mitraki

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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Chrysanthi Pinelopi ApostolidouDepartment of Materials Science and Engineering, University of Crete, Voutes Campus, 70013 Heraklion, Greece.ORCID 0000-0001-7686-2238

Georgios CharalambidisLaboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.ORCID 0000-0003-1237-9962

Aikaterini GialouriDepartment of Materials Science and Engineering, University of Crete, Voutes Campus, 70013 Heraklion, Greece.

Maria ChatzinikolaidouDepartment of Materials Science and Engineering, University of Crete, Voutes Campus, 70013 Heraklion, Greece.ORCID 0000-0002-2749-2506

Anna MitrakiDepartment of Materials Science and Engineering, University of Crete, Voutes Campus, 70013 Heraklion, Greece.ORCID 0000-0001-5072-1939

Funding

Hellenic Foundation for Research and Innovation (H.F.R.I.) Project Number: 9578

6 · The paper itself

Abstract

Copper and zinc nanoparticles have been suggested as potent anticancer agents, particularly against osteosarcoma, a highly aggressive bone cancer with limited treatment options. In order to avoid systemic toxicity, biomolecular carriers able to chelate metal ions and deliver them in a targeted manner to the vicinity of cancer cells need to be developed. Herein, we have used a histidine-containing, cyclic dipeptide as a carrier able to chelate stabilized copper and zinc nanoparticles. The cyclic peptide cyclo-(histidine-phenylalanine) (cHF) self-assembled into amyloid-type fibrils; morphological and structural characterization following metal addition confirmed the formation of cHF-CuNPs and cHF-ZnNPs. These composite nanoparticles demonstrated bacteriostatic activity against

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsBone NeoplasmsCoordination ComplexesCopperMetal NanoparticlesOsteosarcomaPeptides, CyclicZincAnimalsCell Line, TumorEscherichia coliHumansMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsCoordination ComplexesCopperPeptides, CyclicZincamyloid fibrilsantimicrobial activityfibroblastsmetal nanoparticlesosteosarcomaself-assembling peptides

Identifiers

PMID41750355

DOI10.3390/biom16020284

PMCPMC12938742

What Socratic holds

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