In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Romina Fernández VarelaLaboratorio de Biotransformaciones y Química de Ácidos Nucleicos, Universidad Nacional de Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Roque S. Peña 352, Bernal B1876BXD, Argentina.
Eman AbdelraheemBiocatalysis Group, Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.ORCID 0000-0002-9008-2729 Lautaro GiaimoLaboratorio de Biotransformaciones y Química de Ácidos Nucleicos, Universidad Nacional de Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Roque S. Peña 352, Bernal B1876BXD, Argentina.
Luciano CortésLaboratorio de Biotransformaciones y Química de Ácidos Nucleicos, Universidad Nacional de Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Roque S. Peña 352, Bernal B1876BXD, Argentina.
Leticia LafuenteLaboratorio de Biotransformaciones y Química de Ácidos Nucleicos, Universidad Nacional de Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Roque S. Peña 352, Bernal B1876BXD, Argentina.ORCID 0000-0002-3956-0449 Ana Laura ValinoLaboratorio de Biotransformaciones y Química de Ácidos Nucleicos, Universidad Nacional de Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Roque S. Peña 352, Bernal B1876BXD, Argentina.
Peter-Leon HagedoornBiocatalysis Group, Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.ORCID 0000-0001-6342-2022 Ulf HanefeldBiocatalysis Group, Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.ORCID 0000-0002-4102-6165 Adolfo IribarrenLaboratorio de Biotransformaciones y Química de Ácidos Nucleicos, Universidad Nacional de Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Roque S. Peña 352, Bernal B1876BXD, Argentina.
Elizabeth LewkowiczLaboratorio de Biotransformaciones y Química de Ácidos Nucleicos, Universidad Nacional de Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Roque S. Peña 352, Bernal B1876BXD, Argentina.ORCID 0000-0002-5563-6271 Funding
Universidad Nacional de Quilmes, Agencia Nacional de 515 Promoción Científica y Tecnológica (ANPCYT), National Council of Science and Technology, CO-516 NICET, Argentina, and ERACoBiotech grant 053.80.737; BioDiMet
6 · The paper itselfAbstract
Aldolases are powerful biocatalysts for the stereoselective formation of carbon-carbon bonds and are widely used in the synthesis of chiral intermediates for pharmaceutical applications. Among them, 2-deoxyribose-5-phosphate aldolase (DERA) has been extensively exploited for the preparation of the conserved side chain of statins. In this work, we report a novel chemoenzymatic approach for the synthesis of nucleobase-substituted lactol products as potential precursors of new statin analogues. A C49M variant of DERA from
Indexed as
Aldehyde-LyasesHydroxymethylglutaryl-CoA Reductase InhibitorsAldehydesBiocatalysisAldehyde-LyasesAldehydesdeoxyribose-phosphate aldolaseHydroxymethylglutaryl-CoA Reductase Inhibitors2-deoxyribose-5-phosphate aldolase (DERA)aldol additionnucleobasesPectobacterium atrosepticumstatins
Identifiers
PMID41750389
PMCPMC12937707
What Socratic holds
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