Evidence map›Paper›PMID 41750536›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Heme as a Pro-Inflammatory Stimulus in Abdominal Aortic Aneurysm.

Yuchao Ding, László Potor, Péter Sótonyi, Ágnes Szappanos, Gergő Péter Gyurok, Szilárd Póliska, Andreas Patsalos, Gábor Méhes, Lívia Beke, Katalin Éva Sikura and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yuchao DingDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
László PotorDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0001-9336-8637
Péter SótonyiHeart and Vascular Center, Department of Vascular Surgery and Endovascular Surgery, Semmelweis University, 1122 Budapest, Hungary.
Ágnes SzappanosHeart and Vascular Centre, Semmelweis University, 1122 Budapest, Hungary.
Gergő Péter GyurokHeart and Vascular Center, Department of Vascular Surgery and Endovascular Surgery, Semmelweis University, 1122 Budapest, Hungary.ORCID 0000-0002-1906-6996
Szilárd PóliskaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-9722-251X
Andreas PatsalosDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, All Children's Hospital, St. Petersburg, FL 33701, USA.ORCID 0000-0002-9022-4985
Gábor MéhesDepartment of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Lívia BekeDepartment of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Katalin Éva SikuraDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-7280-1865
Erzsébet ZavaczkiDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0001-6511-4883
Tamás GállDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Dávid PethőDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0001-7549-5691
Attila FinthaDepartment of Pathology and Experimental Cancer Research, Semmelweis University, 1122 Budapest, Hungary.ORCID 0000-0002-0519-8170
Beáta NagyDepartment of Pathology and Experimental Cancer Research, Semmelweis University, 1122 Budapest, Hungary.
Béla JuhászDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
László NagyDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
György BallaHUN-REN-UD Vascular Pathophysiology Research Group, University of Debrecen, 4032 Debrecen, Hungary.
József BallaDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Funding

BACH1 as a novel pioneer repressor in macrophages: impact on homeostasis and inflammationR01AI185363 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Laszlo Nagy · 2024 to 2026
$1.7M
European Union and the European Social Fund EFOP-3.6.2-16-2017-00006 (LIVE LONGER)HUN-REN-DE 11003Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund TKP2021-EGA-18National Institutes of Health (NIH) R01AI185363NIAID NIH HHS R01 AI185363NKFIH ADVANCED 149734 (J.B.)
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a lethal vascular disease characterized by intramural hemorrhage. This study delineates the signatures of heme and its metabolic imbalance related to progression and inflammation in AAA. Clinical analyses of patients undergoing open AAA surgery show that AAA patients exhibit vascular inflammation, with elevated serum CRP, IL-6, and heme levels correlating with the expression of heme-regulated gene

Indexed as

abdominal aortic aneurysmhemeheme oxygenase-1methemoglobinvascular inflammation

Identifiers

PMID41750536
PMCPMC12938419

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.