Evidence map›Paper›PMID 41750575›Full record

ArticleAntioxidants (Basel, Switzerland)2026

C-Ring Structure-Dependent Redox Properties of Flavonoids Regulate the Expression of Bioactivity.

Taiki Fushimi, Kenta Aso, Takafumi Shimizu, Chie Hirahata, Kento Hiroki, Daichi Shinmura, Yasuyuki Fujii, Mitsugu Akagawa, Ali S Abdelhameed, Vittorio Calabrese and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Taiki FushimiDepartment of Food and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.ORCID 0009-0004-7223-1593
Kenta AsoCentral Research Institute, ITO EN, Ltd., Tokyo 151-8550, Japan.
Takafumi ShimizuDepartment of Bioscience and Engineering, Faculty of System Science and Engineering, Shibaura Institute of Technology, Saitama 337-857, Japan.ORCID 0009-0007-8352-4887
Chie HirahataDepartment of Bioscience and Engineering, Faculty of System Science and Engineering, Shibaura Institute of Technology, Saitama 337-857, Japan.
Kento HirokiDepartment of Bioscience and Engineering, Faculty of System Science and Engineering, Shibaura Institute of Technology, Saitama 337-857, Japan.
Daichi ShinmuraDepartment of Bioscience and Engineering, Faculty of System Science and Engineering, Shibaura Institute of Technology, Saitama 337-857, Japan.
Yasuyuki FujiiSIT Laboratory, Shibaura Institute of Technology, Saitama 337-857, Japan.ORCID 0000-0003-1417-0484
Mitsugu AkagawaDepartment of Food and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.ORCID 0000-0002-8735-4738
Ali S AbdelhameedDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-5910-2832
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy.ORCID 0000-0002-0478-985X
Shu TairaFaculty of Food and Agricultural Sciences, Fukushima University, Fukushima 960-1248, Japan.ORCID 0000-0002-9243-0395
Yoshitomo SuharaSystems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama 337-8570, Japan.ORCID 0000-0002-4770-2910
Naomi OsakabeSystems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama 337-8570, Japan.ORCID 0000-0001-8159-7053

Funding

JSPS 23KJ1922King Saud University RSPD2025R750
6 · The paper itself

Abstract

(-)-Epicatechin (EC), taxifolin (Tax), and quercetin (Q) are flavonoids with different C-ring structures. We compared their physicochemical properties and biological activities. The comparison of their stability and redox properties was conducted at mildly acidic or neutral conditions mimicking the plant vacuole or gut, and their sympathetic hyperactivation ability was examined using catecholamine (CA) excretion and blood flow. At pH 5, flavonoids were stable, but at pH 7, their retention rates decreased in the order EC > Q > Tax. LC-MS analysis detected brown oxidized oligomers in EC, while Tax and Q primarily yielded degradation products. All flavonoids exhibited O

Indexed as

C-ringflavonoidreactive oxygen speciesstabilitysympathetic nerve

Identifiers

PMID41750575
PMCPMC12938522

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.