Evidence map›Paper›PMID 41750587›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Lipid Peroxidation Products 4-ONE and 4-HNE Modulate Voltage-Gated Sodium Channels in Neuronal Cell Lines and DRG Action Potentials.

Ming-Zhe Yin, Na Kyeong Park, Mi Seon Seo, Jin Ryeol An, Hyun Jong Kim, JooHan Woo, Jintae Kim, Min Yan, Sung Joon Kim, Seong Woo Choi

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ming-Zhe YinDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.ORCID 0000-0002-2603-284X
Na Kyeong ParkDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Mi Seon SeoDepartment of Physiology, College of Medicine, Dongguk University, 123 Dongdae-ro, Gyeongju 38066, Republic of Korea.
Jin Ryeol AnDepartment of Physiology, College of Medicine, Dongguk University, 123 Dongdae-ro, Gyeongju 38066, Republic of Korea.
Hyun Jong KimDepartment of Physiology, College of Medicine, Dongguk University, 123 Dongdae-ro, Gyeongju 38066, Republic of Korea.ORCID 0000-0002-6130-7028
JooHan WooDepartment of Physiology, College of Medicine, Dongguk University, 123 Dongdae-ro, Gyeongju 38066, Republic of Korea.ORCID 0000-0001-5152-8057
Jintae KimDepartment of Biochemistry & Molecular Biology, College of Medicine, Hanyang University, Wangsimni-ro 222, Seongdong-gu, Seoul 04763, Republic of Korea.
Min YanDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Sung Joon KimDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.ORCID 0000-0002-0289-121X
Seong Woo ChoiDepartment of Physiology, College of Medicine, Dongguk University, 123 Dongdae-ro, Gyeongju 38066, Republic of Korea.ORCID 0000-0002-7906-495X

Funding

National Research Foundation of Korea (NRF) RS-2023-00213304National Research Foundation of Korea (NRF) RS-2024-00456454National Research Foundation of Korea (NRF) RS-2025-02303718
6 · The paper itself

Abstract

Oxidative stress-induced lipid peroxidation products (LPPs), particularly 4-hydroxy-nonenal (4-HNE) and 4-oxo-nonenal (4-ONE), have recently gained attention for their direct regulation of ion channels essential for pain signaling. In this study, we investigated how these two LPPs affect the electrophysiological properties of neurons, specifically voltage-gated sodium (Na

Indexed as

4-hydroxy-nonenal4-oxo-nonenaldorsal root ganglionvoltage-gated sodium channels

Identifiers

PMID41750587
PMCPMC12938110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.