Evidence map›Paper›PMID 41750598›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Design and Synthesis of Caffeine-Based Derivatives with Antioxidant and Neuroprotective Activity: In Vitro Evaluation and SwissADME Profiling.

Denitsa Stefanova, Alime Garip, Virginia Tzankova, Stefan Kostov, Emilio Mateev, Alexander Zlatkov, Yavor Mitkov

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Denitsa StefanovaDepartment of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-6859-9369
Alime GaripDepartment of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1431 Sofia, Bulgaria.ORCID 0009-0008-9216-1544
Virginia TzankovaDepartment of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1431 Sofia, Bulgaria.
Stefan KostovDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 1431 Sofia, Bulgaria.ORCID 0009-0001-4272-3579
Emilio MateevDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-5885-7213
Alexander ZlatkovDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-1695-8454
Yavor MitkovDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 1431 Sofia, Bulgaria.

Funding

European Union - NextGenerationEU BG-RRP-2.004-0004-C01
6 · The paper itself

Abstract

Oxidative stress and excitotoxicity are key contributors to neuronal damage in various neurodegenerative diseases. Caffeine, a widely used neuroactive compound with moderate antioxidant properties, may benefit from structural modifications to enhance its neuroprotective potential. In this study, a series of novel caffeine derivatives was synthesized and evaluated for antioxidant and potential neuroprotective relevance using in vitro models of oxidative stress and glutamate-induced excitotoxicity in SH-SY5Y human neuroblastoma cells. Antioxidant capacity was assessed using ABTS•

Indexed as

antioxidant activitycaffeine derivativesin vitro modelsneuroprotectionoxidative stressreactive oxygen speciesSH-SY5Y cells

Identifiers

PMID41750598
PMCPMC12938810

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.