Evidence map›Paper›PMID 41750629›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts.

Lauren Pavelich, Tasnim Arroum, Lucynda Pham, Dragana Komnenov, Paul M Stemmer, Rachel Lax, Ann Saada, Sarah Weksler-Zangen, Maik Hüttemann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lauren PavelichCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.ORCID 0009-0007-6229-623X
Tasnim ArroumCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.ORCID 0009-0004-9644-3494
Lucynda PhamCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.ORCID 0009-0008-0872-4843
Dragana KomnenovDepartment of Physiology, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0001-8855-4291
Paul M StemmerInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0003-3315-9846
Rachel LaxFaculty of Medicine Hebrew, University of Jerusalem, Jerusalem 9112102, Israel.
Ann SaadaFaculty of Medicine Hebrew, University of Jerusalem, Jerusalem 9112102, Israel.ORCID 0000-0003-2951-0656
Sarah Weksler-ZangenFaculty of Medicine Hebrew, University of Jerusalem, Jerusalem 9112102, Israel.
Maik HüttemannCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0001-6310-7081

Funding

Chief Scientist Office (Israeli Dairy Board) 3-19245Foundation for the National Institutes of Health GM116807Israel Science Foundation 2432/23
6 · The paper itself

Abstract

Mitochondrial dysfunction contributes to diabetic cardiomyopathy, yet how genetic predisposition and diet interact to reshape cardiac metabolism in diabetic and prediabetic states remains unclear. The Cohen diabetic rat model, comprising diabetes-resistant (CDr) and diabetes-sensitive (CDs) strains, provides a unique platform to dissect this interplay. Here, we present an integrative global proteomic and bioenergetic characterization of cardiac tissue from CDr and CDs rats fed either a regular or a diabetogenic diet. Proteomic pathway mapping revealed downregulation of cytochrome

Indexed as

cardiomyopathyCcO6ACcO7Acytochrome c oxidaseheart mitochondriamitochondrial dysfunctionmitochondrial quality controlphosphorylationproteomic characterizationregulationrespirationsupercomplexestype 2 diabetestyrosine 304 phosphorylation

Identifiers

PMID41750629
PMCPMC12937826

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.