Evidence map›Paper›PMID 41750700›Full record

ReviewDiagnostics (Basel, Switzerland)2026

Diagnosis of Tuberculous Meningitis: Integrating Clinical Assessment and Molecular Diagnostics.

Jorge E Leiva-Ordoñez, Beatriz Quintero

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jorge E Leiva-OrdoñezSchool of Medicine, Universidad Técnica Particular de Loja, Loja 110101, Ecuador.ORCID 0000-0002-7570-9108
Beatriz QuinteroSchool of Medicine, Universidad Técnica Particular de Loja, Loja 110101, Ecuador.ORCID 0000-0002-1084-9185

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculous meningitis is the most severe form of tuberculosis and remains associated with high mortality and substantial neurological disability, particularly among children and people living with HIV. Early diagnosis is challenging because of nonspecific clinical manifestations, the limited discriminatory value of cerebrospinal fluid cytochemical analysis, and the low sensitivity of conventional microbiological methods. This narrative review synthesizes contemporary evidence on the diagnostic approach to tuberculous meningitis, integrating clinical assessment, paraclinical cerebrospinal fluid findings, conventional microbiology, and molecular diagnostic tools. Clinical scoring systems, including the uniform case definition (Lancet consensus score), improve diagnostic stratification but do not replace microbiological confirmation. Molecular assays have transformed diagnostic pathways by enabling rapid detection of

Indexed as

cerebrospinal fluidhigh-throughput nucleotide sequencingmeningealmolecular diagnostic techniquesnucleic acid amplification techniquestuberculosis

Identifiers

PMID41750700
PMCPMC12939813

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.