Evidence mapPaperPMID 41750929Full record

ReviewFoods (Basel, Switzerland)2026

Exploring the Multifunctional Roles of Betaine: Traditional Applications, Emerging Technologies, and Green Chemistry Innovations.

Yinuo Liu, Qiuxiao Li, Ruijia Liu, Zelong Wang, Shuna Zhao

Abstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yinuo LiuSchool of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Qiuxiao LiSchool of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Ruijia LiuSchool of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Zelong WangSchool of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Shuna ZhaoSchool of Food and Health, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0002-5016-1449

Funding

Beijing High-level Talent Team Construction Project 19008025035
6 · The paper itself

Abstract

Betaine, a simple natural zwitterion, is currently attracting widespread attention. Although historically labeled as an osmoregulator in agriculture and a methyl donor in animal nutrition, the molecule is now being repositioned at the forefront of green chemistry and materials science due to its unique physicochemical structure. This review critically explores the expanding horizon of betaine applications, bridging the gap between its established biological functions and its emerging roles in recently reported technologies, such as deep eutectic solvents (DESs), cocrystal engineering, and sustainable polymer synthesis. Beyond summarizing its versatile functionality across biomedicine, food science, and industrial formulations, we provide a comprehensive bibliometric analysis to map the evolution of research trends, identifying a clear focus toward industrial ecology and advanced materials. By synthesizing current advancements and discussing potential future directions, this work highlights betaine not merely as a supplement, but as a versatile molecular component with potential applications in sustainable materials and chemical engineering processes.

Indexed as

betainebibliometric analysiscocrystalsdeep eutectic solvents (DESs)green chemistrytraditional applications

Identifiers

PMID41750929
PMCPMC12939989

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.