Evidence map›Paper›PMID 41751442›Full record

ArticleCurrent issues in molecular biology2026

Genetic and Epigenetic Mechanisms in Serrated Adenocarcinomas and Classical Colorectal Carcinomas: An In Silico Study.

Zeynep Sagnak Yilmaz, Sibel Demir Kececi, Ozgul Sagol, Sulen Sarioglu

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zeynep Sagnak YilmazDepartment of Pathology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Türkiye.
Sibel Demir KececiDepartment of Molecular Pathology, Graduate School of Health Sciences, Dokuz Eylul University, 35220 Izmir, Türkiye.
Ozgul SagolDepartment of Molecular Pathology, Graduate School of Health Sciences, Dokuz Eylul University, 35220 Izmir, Türkiye.
Sulen SariogluDepartment of Pathology, Faculty of Medicine, Izmir University of Economics, 35330 Izmir, Türkiye.ORCID 0000-0003-4877-3064

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serrated adenocarcinoma (SAC) represents a molecularly heterogeneous subtype of colorectal carcinoma (CRC) linked to the serrated pathway. It is aimed to clarify the molecular mechanisms underlying SAC development. Digital slides from The Cancer Genome Atlas (TCGA) colorectal adenocarcinoma Firehose Legacy dataset (632 cases) were reviewed, and cases were classified as SAC, partial-SAC, or classical CRC. Genomic alterations, mRNA expression, and DNA hypermethylation were compared using cBioPortal. Enrichment analyses were performed via WebGestalt, and protein-protein interaction (PPI) networks with hub genes were identified using STRING and Cytoscape. Statistical significance was defined as

Indexed as

colorectal carcinomaepigeneticin silicoserrated adenocarcinomasomatic mutation

Identifiers

PMID41751442
PMCPMC12939040

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.