Evidence map›Paper›PMID 41751779›Full record

ArticleInternational journal of molecular sciences2026

Stage-Dependent Role of Eicosanoids in Colorectal Cancer.

Jakub Klekowski, Paulina Fortuna, Mariusz Chabowski, Łukasz Lewandowski, Wioleta Szewczak, Karolina Mosna, Gabriela Maciejewska, Marek Zawadzki, Małgorzata Krzystek-Korpacka, Mariusz Fleszar

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jakub KlekowskiDepartment of Surgery, 4th Military Clinical Hospital, 50-981 Wroclaw, Poland.ORCID 0000-0001-8017-9730
Paulina FortunaOmics Research Center, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0003-4617-798X
Mariusz ChabowskiDepartment of Surgery, 4th Military Clinical Hospital, 50-981 Wroclaw, Poland.ORCID 0000-0002-9232-4525
Łukasz LewandowskiDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0002-7624-631X
Wioleta SzewczakOmics Research Center, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Karolina MosnaOmics Research Center, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0001-5248-3399
Gabriela MaciejewskaOmics Research Center, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0009-0004-9804-4032
Marek ZawadzkiDepartment of Clinical Surgical Sciences, Faculty of Medicine, Wroclaw University of Science and Technology, 50-556 Wroclaw, Poland.ORCID 0000-0001-8957-5625
Małgorzata Krzystek-KorpackaDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0002-2753-8092
Mariusz FleszarOmics Research Center, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0001-7857-327X

Funding

NextGenerationEU KPOD.07.07-IW.07-0073/24
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a major health concern with increasing incidence, especially in younger adults. This study evaluated the stage-dependent role of serum eicosanoids as biomarkers in CRC patients. A cohort of 122 patients undergoing curative colorectal resection was prospectively recruited. Serum eicosanoid profiles were evaluated using targeted metabolomics and analyzed through regression-based statistical models to identify associations with CRC staging. The more advanced stages of CRC (with N+ and M+) showed significantly increased levels of PGD

Indexed as

Biomarkers, TumorColorectal NeoplasmsEicosanoidsAgedFemaleHumansLeukotriene B4MaleMetabolomicsMiddle AgedNeoplasm StagingProstaglandin D2Biomarkers, TumorEicosanoidsLeukotriene B4Prostaglandin D2colorectal cancereicosanoidslipidomicsprostaglandinsthromboxanes

Identifiers

PMID41751779
PMCPMC12941361

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.