Gender-Related Differences in Cerebrovascular Reactivity to L-Arginine in Middle-Aged Type 1 Diabetes Patients.

Grzegorz M Kozera, Jolanta Neubauer-Geryk, Bogumił Wolnik, Sebastian Szczyrba, Leszek Bieniaszewski

Abstract read

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Grzegorz M KozeraMedical Simulation Centre, Medical University of Gdansk, 80-210 Gdansk, Poland.ORCID 0000-0001-7704-2434

Jolanta Neubauer-GerykMedical Simulation Centre, Medical University of Gdansk, 80-210 Gdansk, Poland.ORCID 0000-0002-9175-3862

Bogumił WolnikDepartment of Hypertension and Diabetology, Medical University of Gdansk, 80-210 Gdansk, Poland.

Sebastian SzczyrbaDepartment of Neurology, Medical University of Gdansk, 80-210 Gdansk, Poland.ORCID 0000-0002-8095-7691

Leszek BieniaszewskiMedical Simulation Centre, Medical University of Gdansk, 80-210 Gdansk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes (T1D) increases the risk for cerebral microangiopathy. However, the association between gender and cerebral microcirculatory dysfunction in T1D remains undetermined. Therefore, we have conducted a comparative analysis of cerebral endothelial-mediated microcirculatory parameters between middle-aged Caucasian females and males with type 1 diabetes. The present study examined the nitric oxide-induced vasomotor reactivity of middle cerebral arteries (MCA using transcranial Doppler and L-arginine infusion (L-arg VMR)). The study compared L-arg VMR between 23 males and 26 females with type 1 diabetes without a history of overt cerebrovascular disease. Mean L-arg VMR and baseline MCA flow velocity (V rest) were higher in females than in males (20.1 ± 5.4 vs. 14.6 ± 7.1%

Indexed as

ArginineCerebrovascular CirculationDiabetes Mellitus, Type 1AdultFemaleHumansMaleMicrocirculationMiddle AgedMiddle Cerebral ArteryNitric OxideSex FactorsArginineNitric Oxidecerebral microangiopathygenderL–argininemiddle cerebral arterytranscranial Dopplertype 1 diabetesvasomotor reactivity

Identifiers

PMID41751798

DOI10.3390/ijms27041662

PMCPMC12941136

What Socratic holds

Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.