Evidence map›Paper›PMID 41751893›Full record

ArticleInternational journal of molecular sciences2026

Neurotoxic Effect of Manganese and Vanadium Co-Exposure in Animal Models of Parkinson's Disease.

Alejandra Bargues-Carot, Naveen Kondru, Maddlyn Haller, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasamy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alejandra Bargues-CarotIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Naveen KondruIowa Center for Advanced Neurotoxicology, Department of Biomedical Science, Iowa State University, Ames, IA 50011, USA.
Maddlyn HallerIowa Center for Advanced Neurotoxicology, Department of Biomedical Science, Iowa State University, Ames, IA 50011, USA.ORCID 0009-0000-3261-0485
Gary ZenitskyIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0003-1214-3247
Huajun JinIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Vellareddy AnantharamIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Arthi KanthasamyIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Anumantha G KanthasamyIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.

Funding

United States Department of Defense W81XWH1810106
6 · The paper itself

Abstract

Chronic environmental exposure to mixtures of heavy metals like manganese (Mn) and vanadium (V) has been associated with Parkinson's disease (PD). We investigated the poorly understood neurotoxic effects of Mn/V co-exposure on PD-relevant behavioral phenotypes in transgenic mice expressing the human alpha-synuclein (αSyn) A53T mutant. C57BL/6 wild-type (WT) and transgenic A53T mice were intranasally co-exposed to 100 µg MnCl

Indexed as

ManganeseParkinson DiseaseVanadiumalpha-SynucleinAnimalsBehavior, AnimalBrainDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicMotor Activityalpha-SynucleinManganeseVanadiummanganesemetal exposuremixturesParkinsonismvanadiumα-synuclein

Identifiers

PMID41751893
PMCPMC12940837

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.