Evidence map›Paper›PMID 41751901›Full record

ArticleInternational journal of molecular sciences2026

The Role of Elafin in the Pathogenesis of Psoriasis.

Mateusz Matwiejuk, Agnieszka Kulczyńska-Przybik, Bartłomiej Łukaszuk, Hanna Myśliwiec, Piotr Myśliwiec, Adrian Chabowski, Barbara Mroczko, Iwona Flisiak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mateusz MatwiejukDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0000-0002-2873-4001
Agnieszka Kulczyńska-PrzybikDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
Bartłomiej ŁukaszukDepartment of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.ORCID 0000-0002-4954-3431
Hanna MyśliwiecDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0000-0003-1948-0545
Piotr Myśliwiec1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, 15-276 Bialystok, Poland.
Adrian ChabowskiDepartment of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.ORCID 0000-0002-7407-8156
Barbara MroczkoDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.ORCID 0000-0002-4075-8479
Iwona FlisiakDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0000-0002-5923-910X

Funding

Medical University of Bialystok B.SUB.24.230
6 · The paper itself

Abstract

Psoriasis is a chronic, immune-mediated inflammatory disease that affects the skin, nails, joints, and cardiovascular system. In this study, involving 50 psoriatic patients and 28 healthy controls (patients with inguinal hernia), serum elafin levels were measured using enzyme-linked immunosorbent assay (ELISA). The results revealed significantly higher serum elafin levels in the psoriatic group compared to healthy individuals. Moreover, we observed a statistically significant positive correlation between serum elafin levels and the Psoriasis Area and Severity Index (PASI) scores. These findings indicate that elafin-a protein involved in psoriasis pathogenesis-is significantly altered in the serum of psoriatic patients and may be associated with disease severity.

Indexed as

ElafinPsoriasisAdultBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexBiomarkersElafinelafinproteinpsoriasisskin diseases

Identifiers

PMID41751901
PMCPMC12940578

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.