Evidence map›Paper›PMID 41751920›Full record

ArticleInternational journal of molecular sciences2026

Integrated Single-Cell Multi-Omics Analysis Reveals That a CD8

Yusen Zhao, Xinrong Li, Wenbo Dong, Hongbo Zhu, Shuangshuang Wang, Manyi Xu, Yongle Xu, Mengmeng Liu, Junjie Duan, Yujie Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yusen ZhaoCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Xinrong LiCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Wenbo DongCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Hongbo ZhuCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Shuangshuang WangCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Manyi XuCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Yongle XuCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Mengmeng LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Junjie DuanCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Yujie LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Wei FengCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.
Shangwei NingCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.ORCID 0000-0003-4079-8945
Hui ZhiCollege of Bioinformatics Science and Technology, Harbin Medical University, 157th Rd of Baojian Nangang Distinct, Harbin 150081, China.ORCID 0000-0001-9103-8642

Funding

National Natural Science Foundation of China 32170674
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a major public health issue, and the role of peripheral immunity in its pathogenesis remains poorly understood. This study conducted a comprehensive reanalysis of publicly available single-cell transcriptomic and chromatin accessibility datasets to investigate immune cell dynamics in AD. By integrating data from cerebrospinal fluid and peripheral blood samples, we constructed a cross-tissue immune cell atlas. Based on Monocle3 pseudotemporal trajectory analysis, we propose the hypothesis that CD8

Indexed as

Alzheimer DiseaseCD8-Positive T-LymphocytesMonocytesSingle-Cell AnalysisBlood-Brain BarrierCell CommunicationHumansMultiomicsAlzheimer’s diseaseimmune infiltrationsingle-cell multi-omics

Identifiers

PMID41751920
PMCPMC12941315

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.