Evidence map›Paper›PMID 41751950›Full record

ArticleInternational journal of molecular sciences2026

Synthesis and Antitumor Potency of 2

Irina Smirnova, Zarema Galimova, Alexander Lobov, Anastasiia Mikheenko, Irina Khan, Gulalek Babayeva, Vadim S Pokrovsky, Oxana Kazakova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Irina SmirnovaUfa Institute of Chemistry UFRC RAS, 71, pr. Oktyabrya, Ufa 450054, Russia.ORCID 0000-0001-7176-505X
Zarema GalimovaUfa Institute of Chemistry UFRC RAS, 71, pr. Oktyabrya, Ufa 450054, Russia.
Alexander LobovUfa Institute of Chemistry UFRC RAS, 71, pr. Oktyabrya, Ufa 450054, Russia.ORCID 0000-0002-9223-508X
Anastasiia MikheenkoN.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 23, Moscow 115522, Russia.ORCID 0009-0009-2158-3915
Irina KhanN.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 23, Moscow 115522, Russia.ORCID 0000-0003-2948-0872
Gulalek BabayevaN.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 23, Moscow 115522, Russia.ORCID 0000-0001-5781-7925
Vadim S PokrovskyN.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 23, Moscow 115522, Russia.ORCID 0000-0003-4006-9320
Oxana KazakovaUfa Institute of Chemistry UFRC RAS, 71, pr. Oktyabrya, Ufa 450054, Russia.ORCID 0000-0002-5606-1588

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Michael acceptors, such as chalcones and benzylidenes, are privileged scaffolds for the development of anticancer agents. Taking this into account, we developed a selective Claisen-Schmidt condensation of the dammarane-type triterpenoid hollongdione with pyridine-2-carbaldehyde, enabling controlled synthesis of mono- and bis-substituted triterpenes depending on the reaction conditions. The reaction demonstrated high temperature-dependent regioselectivity, providing C2-mono-

Indexed as

Antineoplastic AgentsTriterpenesAnimalsCell Line, TumorCell ProliferationCrystallography, X-RayDrug Screening Assays, AntitumorHumansPyridinesZebrafishAntineoplastic AgentshollongdionePyridinesTriterpenesantiproliferative activityClaisen–Schmidt condensationdammaraneDipterocarpus alatushollongdioneMichael acceptorNCI-60triterpenoidszebrafish (Danio rerio)

Identifiers

PMID41751950
PMCPMC12941353

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.