Spexin as a Novel Biomarker for Predicting Disease Severity and Mortality in Acute Pancreatitis.

Betül Çiğdem Yortanlı, Ümmügülsüm Can, Tevhide Şahin, Mehmet Yortanlı, Oğuzhan Aksu

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Betül Çiğdem YortanlıDepartment of Internal Medicine, University of Health Sciences, Konya City Hospital, 42060 Konya, Turkey.ORCID 0000-0003-2698-3159

Ümmügülsüm CanDepartment of Biochemistry, University of Health Sciences, Konya City Hospital, 42060 Konya, Turkey.

Tevhide ŞahinDivision of Gastroenterology, Department of Internal Medicine, University of Health Sciences, Konya City Hospital, 42060 Konya, Turkey.

Mehmet YortanlıDepartment of Emergency Medicine, Konya Numune Hospital, 42020 Konya, Turkey.ORCID 0000-0002-6744-2423

Oğuzhan AksuDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Health Sciences, Konya City Hospital, 42060 Konya, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the diagnostic and prognostic value of serum spexin levels in patients with acute pancreatitis (AP) and to assess their association with disease severity and mortality. A total of 34 AP patients and 34 healthy individuals were included in the study. AP patients were classified into three groups: mild, moderately severe, and severe (SAP). Serum spexin levels were measured using ELISA, and biochemical parameters, inflammatory indices, and clinical scores were compared. Univariate logistic regression analysis was performed to evaluate factors associated with AP severity and mortality, and ROC analysis was used to assess the diagnostic performance. The median spexin level in AP patients was significantly higher than in healthy controls (

Indexed as

BiomarkersPancreatitisPeptide HormonesAcute DiseaseAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedPrognosisROC CurveSeverity of Illness IndexBiomarkersPeptide HormonesSPX protein, humanacute pancreatitisbiomarkersmortalitysevere acute pancreatitisspexin

Identifiers

PMID41751978

DOI10.3390/ijms27041845

PMCPMC12940907

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.