ReviewInternational journal of molecular sciences2026
Immunomodulatory Effects of Flavonoids in Colitis-Associated Colorectal Cancer.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Enhancing Targeted Colorectal Cancer Therapies with Natural Products: Mechanistic Pathways.Biomedicines · 2026Review
- Two Flavones as Markers for the Distinction of Natural Acacia Honey Based on the UHPLC-QE-MS Method and Research on Their Potential Immunomodulatory Activity.Food science & nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Flavonoids present in plants and fruits have been used in traditional medicine to reduce inflammation under various inflammatory conditions, including colitis. The pharmacological mechanisms that regulate intestinal inflammation are associated with the colonic microbiota, protection against oxidative stress, preservation of epithelial barrier function, and immune homeostasis. This review describes the main flavonoids present in the diet and examines their role in mitigating colon inflammation, as well as their impact when chronic inflammation progresses to colitis-associated colorectal cancer (CAC), in which flavonoids may promote immune evasion and tumor growth. Understanding the effects of flavonoids on colon physiology offers an opportunity to use these compounds rationally in the treatment of colitis and prevention of the development of colorectal cancer (CRC).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.