Evidence map›Paper›PMID 41752033›Full record

ReviewInternational journal of molecular sciences2026

Molecular Insights and Orthopedic Management in Muscular Dystrophies: A Comprehensive Review.

Jan Lejman, Michał Pytlak, Anna Danielewicz, Erich Rutz, Michał Latalski, Monika Lejman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jan LejmanDepartment of Children's Neurology, Medical University of Lublin, 20-093 Lublin, Poland.
Michał PytlakDepartment of Children's Neurology, University Children's Hospital in Lublin, 20-093 Lublin, Poland.ORCID 0009-0007-0036-6298
Anna DanielewiczChildren's Orthopaedic Department, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-0884-7498
Erich RutzDepartment of Orthopaedics, The Royal Children's Hospital, Melbourne 3010, Australia.ORCID 0000-0002-2292-0946
Michał LatalskiChildren's Orthopaedic Department, Medical University of Lublin, 20-093 Lublin, Poland.
Monika LejmanIndependent Laboratory of Genetic Diagnostics, Medical University of Lublin, 20-093 Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle degeneration is the hallmark of muscular dystrophies-genetically heterogeneous disorders traditionally approached through the lens of molecular pathogenesis or symptomatic management in isolation. Here, we present a deliberately interdisciplinary synthesis that bridges molecular genetics, clinical phenotyping, and evidence-based orthopedic decision-making to address a significant critical gap: the lack of genotype-informed, function-oriented frameworks for musculoskeletal complications. We re-evaluate disease entities-not only by their molecular etiology (e.g., DMD, LMNA, DUX4 dysregulation), but through the prism of orthopedic manifestations as diagnostic gateways and therapeutic milestones. For instance, early rigid spine in

Indexed as

Muscular DystrophiesHumansgene therapymolecular pathogenesismuscle degenerationmuscular dystrophiesorthopedic managementprecision medicine

Identifiers

PMID41752033
PMCPMC12940773

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.