Evidence map›Paper›PMID 41752049›Full record

ArticleInternational journal of molecular sciences2026

Targeting Skin Aging at Multiple Fronts: Integrated In Silico and In Vitro Evidence of Antioxidant, Anti-Protease, and UVB-Protective Effects of

Putu Gita Maya Widyaswari Mahayasih, Pietradewi Hartrianti, Arli Aditya Parikesit, Chelsea Clarisa, Farras Kayla Thallah Widodo, Novita Dwi Lestari, Mario Lawrence Wirawan, Redhalfi Fadhila, Erika Chriscensia, Abdul Mun'im and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Putu Gita Maya Widyaswari MahayasihFaculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia.
Pietradewi HartriantiSchool of Health and Life Sciences, I3L University, East Jakarta 13210, Jakarta, Indonesia.ORCID 0000-0002-5315-6741
Arli Aditya ParikesitSchool of Health and Life Sciences, I3L University, East Jakarta 13210, Jakarta, Indonesia.ORCID 0000-0001-8716-3926
Chelsea ClarisaSchool of Health and Life Sciences, I3L University, East Jakarta 13210, Jakarta, Indonesia.
Farras Kayla Thallah WidodoFaculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia.
Novita Dwi LestariSchool of Health and Life Sciences, I3L University, East Jakarta 13210, Jakarta, Indonesia.
Mario Lawrence WirawanSchool of Health and Life Sciences, I3L University, East Jakarta 13210, Jakarta, Indonesia.ORCID 0009-0000-1593-9641
Redhalfi FadhilaFaculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia.
Erika ChriscensiaSchool of Health and Life Sciences, I3L University, East Jakarta 13210, Jakarta, Indonesia.ORCID 0000-0002-6758-3381
Abdul Mun'imFaculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia.
Richard Johari JamesIntegrative Pharmacogenomics Institute, Universiti Teknologi MARA, Bandar Puncak Alam 42300, Selangor, Malaysia.ORCID 0000-0003-4138-615X
Syariful MubarokDepartment of Agronomy, Faculty of Agriculture, Universitas Padjadjaran, Bandung 45360, West Java, Indonesia.ORCID 0000-0002-0890-3090
Choo Chee YanFaculty of Pharmacy, Universiti Teknologi MARA, Bandar Puncak Alam 42300, Selangor, Malaysia.
Donna Maretta AriestantiFaculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia.ORCID 0000-0002-0917-0538

Funding

University of Indonesia (PUTI) NKB-174/UN2.RST/HKP.05.00/2024
6 · The paper itself

Abstract

Skin aging is driven by oxidative stress, extracellular matrix degradation, and ultraviolet-B (UVB)-induced cellular injury. Plant-derived bioactives with multi-targeted protective actions offer promising avenues for cosmeceutical development. This study assessed ethanolic leaf extracts of

Indexed as

AntioxidantsPlant ExtractsSkin AgingUltraviolet RaysVitexFlavonoidsHaCaT CellsHumansKeratinocytesMolecular Docking SimulationOxidative StressPancreatic ElastasePhytochemicalsPlant LeavesAntioxidantsFlavonoidsPancreatic ElastasePhytochemicalsPlant Extractsantioxidant activityelastase and collagenase inhibitionin silico dockingUVB-induced skin agingVitex trifolia

Identifiers

PMID41752049
PMCPMC12940523

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.