Evidence map›Paper›PMID 41752058›Full record

ArticleInternational journal of molecular sciences2026

An Exploratory Biomarker Study of First-Trimester Circulating miRNAs Associated with Later Gestational Diabetes Mellitus.

Miguel Angel Déctor, Valeria Carmen Macías-González, Adriana Sánchez-García, Armando Hernández-Mendoza, Natalia Martínez-Acuña, Ana María Rivas-Estilla, José Gerardo González-González, María Carmen Barboza-Cerda

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Miguel Angel DéctorFacultad de Agronomía, Universidad Autónoma de Nuevo León, Ex Hacienda El Cañada, General Escobedo 66050, Nuevo León, Mexico.ORCID 0000-0001-8012-3702
Valeria Carmen Macías-GonzálezIndependent Researcher, García 66024, Nuevo León, Mexico.
Adriana Sánchez-GarcíaServicio de Endocrinología, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Mitras Centro, Monterrey 64460, Nuevo León, Mexico.
Armando Hernández-MendozaCentro de Investigación en Dinámica Celular, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Chamilpa, Cuernavaca 62209, Morelos, Mexico.ORCID 0000-0002-7809-6888
Natalia Martínez-AcuñaFacultad de Medicina Mexicali, Universidad Autónoma de Baja California, Centro Cívico, Mexicali 21000, Baja California, Mexico.
Ana María Rivas-EstillaDepartamento de Bioquímica y Medicina Molecular, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Av. Francisco I. Madero s/n y Dr. Eduardo Aguirre Pequeño, Mitras Centro, Monterrey 64460, Nuevo León, Mexico.ORCID 0000-0003-2311-2534
José Gerardo González-GonzálezServicio de Endocrinología, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Mitras Centro, Monterrey 64460, Nuevo León, Mexico.
María Carmen Barboza-CerdaDepartamento de Bioquímica y Medicina Molecular, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Av. Francisco I. Madero s/n y Dr. Eduardo Aguirre Pequeño, Mitras Centro, Monterrey 64460, Nuevo León, Mexico.ORCID 0000-0002-7305-6676

Funding

Consejo Nacional de Ciencia y Tecnología (CONACYT). F0003-2019-03 Laboratorios Nacional 2019 299077
6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) develops silently during early pregnancy, yet its earliest circulating molecular signatures remain poorly defined. In this exploratory biomarker study, we characterized first-trimester circulating microRNA (miRNAs) associated with later GDM using a pool-based small RNA sequencing approach. Using a systematic and unbiased sequencing strategy with locus-level miRNA resolution, we profiled the first-trimester plasma miRNome and prioritized a set of 18 mature miRNAs from among 255 detected species. Set-level functional enrichment analyses based on curated and predicted miRNA-target interactions derived primarily from cellular and tissue-based studies showed annotation-based convergence on pathways related to Ca

Indexed as

BiomarkersCirculating MicroRNADiabetes, GestationalMicroRNAsPregnancy Trimester, FirstAdultFemaleGene Expression ProfilingHumansPregnancySignal TransductionBiomarkersCirculating MicroRNAMicroRNAscirculating microRNAsearly pregnancygestational diabetes mellitusinsulin secretioninsulin signaling

Identifiers

PMID41752058
PMCPMC12940769

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.