Evidence map›Paper›PMID 41752093›Full record

ArticleInternational journal of molecular sciences2026

Improved Surface Properties and Enhanced Cell Adhesion on Poly-ε-Caprolactone for Heart Valve Tissue Engineering Applications via H

Georg Lutter, Julia Schütrumpf, Jette Anika Seiler, Laura Jesaitis, Viktor Schneider, Holger Kersten, Mario Hasler, Lukas Cyganek, Benjamin Book, Xiling Zhang and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Georg LutterDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein (UKSH), 24105 Kiel, Germany.ORCID 0000-0002-9145-3210
Julia SchütrumpfDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein (UKSH), 24105 Kiel, Germany.
Jette Anika SeilerDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein (UKSH), 24105 Kiel, Germany.
Laura JesaitisPlasma Technology Group, Institute of Experimental and Applied Physics, Christian-Albrechts-University, 24118 Kiel, Germany.
Viktor SchneiderPlasma Technology Group, Institute of Experimental and Applied Physics, Christian-Albrechts-University, 24118 Kiel, Germany.ORCID 0000-0003-3498-205X
Holger KerstenPlasma Technology Group, Institute of Experimental and Applied Physics, Christian-Albrechts-University, 24118 Kiel, Germany.
Mario HaslerLehrfach Variationsstatistik, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany.
Lukas CyganekStem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Benjamin BookDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein (UKSH), 24105 Kiel, Germany.
Xiling ZhangDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein (UKSH), 24105 Kiel, Germany.
Stanislav N GorbDepartment of Functional Morphology and Biomechanics, Zoological Institute, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany.ORCID 0000-0001-9712-7953
Stephanie SellersCardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
David MeierCardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.ORCID 0000-0002-5524-5844
Thomas PuehlerGerman Centre for Cardiovascular Research (DZHK), Partner Site North, 20251 Hamburg, Germany.ORCID 0000-0002-4990-1892
Nina PommertGerman Centre for Cardiovascular Research (DZHK), Partner Site North, 20251 Hamburg, Germany.
Derk FrankGerman Centre for Cardiovascular Research (DZHK), Partner Site North, 20251 Hamburg, Germany.ORCID 0000-0001-7561-075X
Monireh Saeid NiaDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein (UKSH), 24105 Kiel, Germany.ORCID 0009-0004-9399-0441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A tissue-engineered heart valve is a fully functional tissue facilitated through the cultivation of autologous cells on appropriate scaffolds. Scaffold's surface charge and wettability are the main factors that significantly affect cell adhesion, which is known to be favourable on hydrophilic surfaces. Moreover, biocompatible scaffolds that induce minimal immunogenic response are also essential for successful tissue engineering (TE). However, commonly used biocompatible polymers with preferable bulk properties lack desirable surface properties. For example, poly-ε-caprolactone (PCL), which is widely used as a scaffold in TE, is known for its satisfying structural and mechanical properties, but due to its surface characteristics, cell attachment and, consequently, cell growth on this polymer are limited. In this study, we investigated the possible effect of H

Indexed as

Heart Valve ProsthesisHeart ValvesPlasma GasesPolyestersTissue EngineeringTissue ScaffoldsAnimalsBiocompatible MaterialsCell AdhesionCell ProliferationHumansHydrophobic and Hydrophilic InteractionsSurface PropertiesWettabilityBiocompatible MaterialsPlasma GasespolycaprolactonePolyestersbiocompatible polymercell attachmentheart valve tissue engineeringplasma treatmentwettability

Identifiers

PMID41752093
PMCPMC12940435

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.