Evidence map›Paper›PMID 41752095›Full record

ArticleInternational journal of molecular sciences2026

Effect Modification of Trimethylamine N-Oxide and Lipoprotein Insulin Resistance with Post-Transplantation Diabetes After Liver Transplant.

Mateo Chvatal-Medina, Yakun Li, Adrian Post, Margery A Connelly, Han Moshage, Stephan J L Bakker, Vincent E de Meijer, Hans Blokzijl, Robin P F Dullaart, On Behalf Of TransplantLines Investigators

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mateo Chvatal-MedinaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-4310-5657
Yakun LiDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Adrian PostDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-8645-1627
Margery A ConnellyLabcorp, 100 Perimeter Park, Morrisville, NC 27560, USA.ORCID 0000-0002-3917-592X
Han MoshageDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-4764-0246
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-3356-6791
Vincent E de MeijerDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-7900-5917
Hans BlokzijlDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-4240-7506
Robin P F DullaartDepartment of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-3844-5254
On Behalf Of TransplantLines Investigators

Funding

Astellas Pharma (Netherlands)
6 · The paper itself

Abstract

Post-transplant diabetes mellitus (PTDM) is a common complication after liver transplantation. Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite, has been linked to insulin resistance, but epidemiological findings on type 2 diabetes remain inconsistent. The Lipoprotein Insulin Resistance (LP-IR) score is a nuclear magnetic resonance (NMR)-derived marker of insulin resistance, yet its role in PTDM and interaction with TMAO are unknown. Three hundred sixty-seven (367) liver transplant recipients (LTRs) from the TransplantLines cohort were studied. Baseline TMAO and LP-IR score were quantified by NMR spectroscopy. Incident PTDM was defined by international criteria. Associations were tested using logistic regression and Cox proportional regression analysis. Effect modification was tested with interaction terms. Thirty-one out of 246 LTRs at risk developed PTDM after a median follow-up of 7.1 years. Higher TMAO (OR 2.14,

Indexed as

Diabetes MellitusDiabetes Mellitus, Type 2Insulin ResistanceLipoproteinsLiver TransplantationMethylaminesAdultBiomarkersFemaleHumansMaleMiddle AgedBiomarkersLipoproteinsMethylaminestrimethyloxaminelipoprotein insulin resistance scoreliver transplantationpost-transplant diabetes mellitustrimethylamine N-oxide

Identifiers

PMID41752095
PMCPMC12940386

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.