Evidence map›Paper›PMID 41752118›Full record

ReviewInternational journal of molecular sciences2026

Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review.

Mostafa Ahmed Kurdi, Hidayah Alotaibi, Asayel Tawfiq Alkhuraymi, Layyan Nassar Aldahery, Ali Fouad Alhawaj, Hamzah Jehad Aldali

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mostafa Ahmed KurdiBiology Department, College of Science, Taibah University, Medina 42353, Saudi Arabia.ORCID 0009-0004-3442-9523
Hidayah AlotaibiDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0001-7774-038X
Asayel Tawfiq AlkhuraymiBiology Department, Faculty of Science, King Abdul Aziz University, Jeddah 21589, Saudi Arabia.ORCID 0009-0006-0674-5419
Layyan Nassar AldaheryBiology Department, Faculty of Science, King Abdul Aziz University, Jeddah 21589, Saudi Arabia.ORCID 0009-0007-0070-9801
Ali Fouad AlhawajDepartment of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.
Hamzah Jehad AldaliCellular and Molecular Medicine, College of Biomedical Science, University of Bristol, Bristol BS8 1DT, UK.ORCID 0000-0001-8588-0921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a severe, progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons, affecting 0.5 to 2.6 per 100,000 people, with a median survival of 2 to 5 years. It is increasingly seen as a multisystem disorder, sharing essential clinicopathological features with Frontotemporal Dementia (FTD). This convergence arises from overlapping molecular processes, including severe oxidative stress, glutamate-mediated excitotoxicity, mitochondrial dysfunction, and widespread aggregated TDP-43 proteinopathy in both sporadic and familial cases. Several key genetic factors have been identified, particularly mutations in

Indexed as

Amyotrophic Lateral SclerosisGastrointestinal MicrobiomeMicrobiotaAnimalsC9orf72 ProteinDNA-Binding ProteinsGenetic TherapyHumansMutationRNA-Binding Protein FUSSuperoxide Dismutase-1C9orf72 ProteinC9orf72 protein, humanDNA-Binding ProteinsRNA-Binding Protein FUSSOD1 protein, humanSuperoxide Dismutase-1TARDBP protein, humanamyotrophic lateral sclerosisgeneticsmicrobiota

Identifiers

PMID41752118
PMCPMC12941290

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.