Evidence map›Paper›PMID 41752141›Full record

ArticleInternational journal of molecular sciences2026

Gut Microbiome Mediates the Causal Link Between Autism Spectrum Disorder and Dietary Preferences: A Mendelian Randomization Study.

Yuqi Wu, Oscar W H Wong, Sizhe Chen, Yun Wang, Guoqing Zhang, Ying Gao, Francis K L Chan, Siew Chien Ng, Qi Su

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuqi WuMicrobiota I-Center (MagIC), Hong Kong SAR 999077, China.ORCID 0009-0004-2885-3731
Oscar W H WongDepartment of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR 999077, China.ORCID 0000-0002-0499-6082
Sizhe ChenMicrobiota I-Center (MagIC), Hong Kong SAR 999077, China.ORCID 0009-0008-0937-4873
Yun WangMicrobiota I-Center (MagIC), Hong Kong SAR 999077, China.ORCID 0000-0002-2507-3156
Guoqing ZhangShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200000, China.
Ying GaoShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200000, China.
Francis K L ChanMicrobiota I-Center (MagIC), Hong Kong SAR 999077, China.ORCID 0000-0001-7388-2436
Siew Chien NgMicrobiota I-Center (MagIC), Hong Kong SAR 999077, China.
Qi SuMicrobiota I-Center (MagIC), Hong Kong SAR 999077, China.ORCID 0000-0001-9100-387X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) frequently co-occurs with malnutrition and gut dysbiosis, yet the underlying mechanisms remain poorly understood. Herein, this cross-sectional study first profiles dietary intake differences using dietary records from 210,874 participants (ASD = 232; non-ASD = 210,642; median age = 56.18) from the UK Biobank (UKB). Second, a bi-directional Mendelian Randomization (MR) approach serves to dissect relationships between ASD genetic susceptibility and dietary preferences by leveraging genome-wide association metadata from the iPSYCH-PGC (ASD) and UKB (dietary intake/food-liking traits). The same strategy is implemented to identify ASD-associated gut microbial species. Mediation analyses further assess the role of gut microbiota in the association between ASD and dietary preferences. Subjects with ASD exhibit higher consumption of cheese, processed meat, and oily fish, alongside lower intake of fruits, and demonstrate a preference for high-fat/salt and energy-dense foods. Additionally, the depletion of

Indexed as

Autism Spectrum DisorderFood PreferencesGastrointestinal MicrobiomeAdultCross-Sectional StudiesDietFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle Agedautism spectrum disorderdietary preferencesgut microbiomemediation effects

Identifiers

PMID41752141
PMCPMC12941152

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.