Evidence mapPaperPMID 41752164Full record

SynthesisInternational journal of molecular sciences2026

Analysis of Antimicrobial Peptide Expression Under Acute and Chronic Alcohol Exposure: A Cross-Sectional Study and a Systematic Review of the Literature.

Maura Rojas-Pirela, Cristian Herrera-Flores, Pilar Costa-Alba, Daniel Salete-Granado, María-Lourdes Aguilar, David Puertas-Miranda, Beatriz Cicuéndez, María-Ángeles Pérez-Nieto, Candy Pérez-Albornoz, Cintia Folgueira and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maura Rojas-PirelaDepartment of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-4387-2613
Cristian Herrera-FloresDepartment of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-9048-9609
Pilar Costa-AlbaPrimary Care Management of Salamanca, Castilla and León Health Service (SACyL), 37007 Salamanca, Spain.
Daniel Salete-GranadoDepartment of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain.
María-Lourdes AguilarInstitute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
David Puertas-MirandaDepartment of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-0502-3741
Beatriz CicuéndezOrgan Crosstalk in Metabolic Diseases Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.
María-Ángeles Pérez-NietoDepartment of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-0014-5165
Candy Pérez-AlbornozDepartment of Medicine, University of Salamanca (USAL), 37007 Salamanca, Spain.
Cintia FolgueiraOrgan Crosstalk in Metabolic Diseases Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.ORCID 0000-0003-3803-9149
Alfonso MoraOrgan Crosstalk in Metabolic Diseases Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.ORCID 0000-0002-6397-4836
Guadalupe SabioOrgan Crosstalk in Metabolic Diseases Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.
Miguel MarcosDepartment of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-1269-4487

Funding

ISCIII and cofunded by the European Union CM23/00238
6 · The paper itself

Abstract

Alcohol exposure affects immune regulation and tissue homeostasis. Antimicrobial peptides (AMPs) are essential components of innate immunity, not only defending against pathogens but also modulating processes such as inflammation. However, their tissue-specific regulation in response to alcohol remains poorly characterized, particularly in humans after acute intoxication. We evaluated the expression of AMPs in the peripheral blood of patients with alcohol use disorder (AUD,

Indexed as

AlcoholismAntimicrobial Cationic PeptidesAntimicrobial PeptidesEthanolAcute-Phase ProteinsAdultAnimalsCathelicidinsCross-Sectional StudiesFemaleGene Expression RegulationHumansMaleMiceMiddle AgedAcute-Phase ProteinsAntimicrobial Cationic PeptidesAntimicrobial PeptidesCathelicidinsEthanolalcoholaltered expressionantimicrobial peptidesimmune response

Identifiers

PMID41752164
PMCPMC12940937

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.