Evidence map›Paper›PMID 41752165›Full record

ArticleInternational journal of molecular sciences2026

Immuno-Instructive 3D Tendon Biomimetic Scaffolds Functionalized with Amniotic Epithelial Stem Cell Secretome for Controlled Inflammation and Targeted Macrophage Polarization.

Mohammad El Khatib, Annunziata Mauro, Giuseppe Prencipe, Oriana Di Giacinto, Valeria Giovanna Festinese, Carola Agostinone, Maura Turriani, Paolo Berardinelli, Barbara Barboni, Valentina Russo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammad El KhatibUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-0976-2522
Annunziata MauroUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-3907-0244
Giuseppe PrencipeUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0002-8421-7797
Oriana Di GiacintoUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.
Valeria Giovanna FestineseUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0009-0007-9983-3916
Carola AgostinoneUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0009-0005-5197-4088
Maura TurrianiUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.
Paolo BerardinelliUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.
Barbara BarboniUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-0231-8066
Valentina RussoUnit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-4368-2534

Funding

Ministero dell'università e della ricerca C53D23005440006
6 · The paper itself

Abstract

Tendon healing is often hindered by unresolved inflammation and dysregulated immune responses, highlighting the need for innovative regenerative strategies. This study developed an immune-informed platform by functionalizing validated 3D tendon-mimetic poly(lactide-co-glycolide) (PLGA) scaffolds with immunomodulatory conditioned media (CM), referred to as CM

Indexed as

AmnionBiomimetic MaterialsEpithelial CellsInflammationMacrophagesSecretomeStem CellsTendonsTissue ScaffoldsAnimalsCell ProliferationCells, CulturedCulture Media, ConditionedSheepTissue EngineeringCulture Media, Conditionedamniotic epithelial stem cellsconditioned mediaimmunomodulationmacrophage polarizationscaffold functionalizationtendon regeneration

Identifiers

PMID41752165
PMCPMC12940777

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.