Evidence map›Paper›PMID 41752172›Full record

ArticleInternational journal of molecular sciences2026

Analysis of Consensus Molecular Subtypes of Colorectal Cancer in Oman with Clinicopathologic Correlation.

Shaista Rehman, Asem Shalaby, Said A Al-Busafi, Moon Fai Chan, Shaima Al Khabouri, Mustafa Al Hinai, Adhari Al Zaabi, Mohammad Al Masqari, Asim Qureshi, Mohammed Al-Azri

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Shaista RehmanDepartment of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.ORCID 0009-0003-4040-0236
Asem ShalabyDepartment of Pathology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0001-8032-2306
Said A Al-BusafiGastroenterology and Hepatology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0003-2741-0440
Moon Fai ChanDepartment of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0002-2899-3118
Shaima Al KhabouriDepartment of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0002-5147-9627
Mustafa Al HinaiDepartment of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Adhari Al ZaabiHuman and Clinical Anatomy Department, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0003-4290-1272
Mohammad Al MasqariDepartment of Pathology, The Royal Hospital, Ministry of Health, Muscat 113, Oman.ORCID 0000-0003-4485-0085
Asim QureshiDepartment of Pathology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0002-3793-8372
Mohammed Al-AzriDepartment of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0002-6136-4081

Funding

Oman (HIS Majesty (HM) Strategic Grant) SR/MED/FMCO/23/01
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a major public health challenge in Oman and a leading cause of cancer-related mortality. The rising incidence has been associated with lifestyle changes, urbanization, and genetic factors. The CRC Subtyping Consortium has defined four consensus molecular subtypes (CMS1-CMS4); however, data on their distribution in the Gulf region, including Oman, remain limited. This study aimed to characterize the distribution of CMS subtypes in Omani CRC patients and assess their clinicopathologic correlations using a practical immunohistochemistry (IHC) panel supplemented by a limited targeted molecular approach. This study included 273 CRC patients diagnosed between 2023 and 2024 at two major referral hospitals in Muscat. Initially, the mismatch repair (MMR)-deficient tumors (dMMR) were assigned as CMS1, while the MMR-proficient (pMMR) tumors were further evaluated for β-catenin, P53, KRAS, and TGF-β expression. Mutations in

Indexed as

Colorectal NeoplasmsAdultAgedbeta CateninBiomarkers, TumorDNA Mismatch RepairFemaleHumansImmunohistochemistryMaleMiddle AgedMutationOmanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53beta CateninBiomarkers, TumorProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53colorectal cancerconsensus molecular subtypesimmunohistochemistrymolecular testingOman

Identifiers

PMID41752172
PMCPMC12940371

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.