Evidence map›Paper›PMID 41752190›Full record

ArticleInternational journal of molecular sciences2026

Chronic Histamine Exposure Promotes Melanogenesis via ORAI1-STIM1-Mediated Calcium Signaling Remodeling.

Nhung Thi Hong Van, Hong Thi Lam Phan, Minh Tuan Nguyen, Woo Kyung Kim, Hyun Jong Kim, Joo Hyun Nam

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nhung Thi Hong VanDepartment of Physiology, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.ORCID 0000-0001-7738-8777
Hong Thi Lam PhanDepartment of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0001-9203-6489
Minh Tuan NguyenCollege of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.ORCID 0000-0001-6215-8266
Woo Kyung KimChannelopathy Research Center (CRC), College of Medicine, Dongguk University, Goyang 10326, Republic of Korea.ORCID 0000-0003-0359-3967
Hyun Jong KimDepartment of Physiology, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea.ORCID 0000-0002-6130-7028
Joo Hyun NamDepartment of Physiology, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea.ORCID 0000-0001-8300-6974

Funding

Dongguk University Research Fund 2022
6 · The paper itself

Abstract

Post-inflammatory hyperpigmentation (PIH) is a common pigmentary disorder characterized by excessive melanin production following skin inflammation. Histamine, a key inflammatory mediator, is known to stimulate melanogenesis via H

Indexed as

Calcium SignalingHistamineMelaninsMelanogenesisNeoplasm ProteinsORAI1 ProteinStromal Interaction Molecule 1AnimalsCalciumCell Line, TumorHumansMelanocytesMiceCalciumHistamineMelaninsNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1calcium signalingH2 receptorhistaminemelanogenesisORAI1post-inflammatory hyperpigmentationprimary human melanocytesstore-operated calcium entry

Identifiers

PMID41752190
PMCPMC12940374

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.