Evidence map›Paper›PMID 41752194›Full record

ArticleInternational journal of molecular sciences2026

Identification of Neferine as a DOR Agonist Activating G

Zenghao Bi, Yuting Liang, Xinyu Tang, Yun Shu, Zhuangyuan Xie, Guoqing Xu, Jing Mo, Pang Jit Seng, Yifan Qing, Zhaotong Cong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zenghao BiSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.ORCID 0000-0002-5811-0224
Yuting LiangSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Xinyu TangSchool of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yun ShuSchool of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Zhuangyuan XieSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Guoqing XuInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Jing MoInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Pang Jit SengM. Kandiah Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang 43000, Selangor, Malaysia.
Yifan QingSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Zhaotong CongInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Liang LengInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.ORCID 0000-0002-9629-6808
Shilin ChenInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Funding

National Key R&D Program of China 2025YFC3508601Natural Science Foundation of Sichuan No. 2024ZDZX0019
6 · The paper itself

Abstract

Benzylisoquinoline alkaloids (BIAs) exhibit diverse biological activities, such as neuroprotective effects. The delta-opioid receptor (DOR) has emerged as a promising therapeutic target due to its potential role in enhancing neuroprotection and regeneration. However, reports on the binding of BIAs to the DOR remain scarce. Here, neferine, a BIA from

Indexed as

BenzylisoquinolinesReceptors, Opioid, deltaSignal TransductionComputer SimulationHEK293 CellsHumansMolecular Docking SimulationBenzylisoquinolinesneferineReceptors, Opioid, deltaagonistbenzylisoquinoline alkaloiddelta-opioid receptorneferine

Identifiers

PMID41752194
PMCPMC12940200

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.