Evidence map›Paper›PMID 41752205›Full record

ArticleInternational journal of molecular sciences2026

Exploration of Early-Treatment-Associated Changes in Metabolic and Inflammatory Biomarkers in First-Episode Psychosis in Italian Patients.

Elisabetta Maffioletti, Clarissa Ferrari, Roberta Zanardini, Roberta Rossi, Sarah Tosato, Chiara Bonetto, Mario Ballarin, Antonio Lasalvia, Mirella Ruggeri, Massimo Gennarelli and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisabetta MaffiolettiDepartment of Theoretical and Applied Sciences (DiSTA), eCampus University, 22060 Novedrate, Italy.
Clarissa FerrariFondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy.ORCID 0000-0002-4101-6872
Roberta ZanardiniClinical Laboratory, ASST-Valcamonica, 25040 Esine, Italy.ORCID 0000-0001-7727-0584
Roberta RossiPsychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Sarah TosatoSection of Psychiatry, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-9665-7538
Chiara BonettoSection of Psychiatry, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.ORCID 0000-0001-9895-6403
Mario BallarinSection of Psychiatry, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.ORCID 0000-0003-2880-2382
Antonio LasalviaCenter for Medical Sciences (CISMed), University of Trento, 38122 Trento, Italy.
Mirella RuggeriSection of Psychiatry, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.
Massimo GennarelliDepartment of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.
Andrea GevitiService of Statistics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
On Behalf Of The Get-Up Group
Luisella Bocchio-ChiavettoDepartment of Theoretical and Applied Sciences (DiSTA), eCampus University, 22060 Novedrate, Italy.ORCID 0000-0002-9801-603X

Funding

Italian Ministry of Health Ricerca Finalizzata 2007, Grant code H61J08000200001
6 · The paper itself

Abstract

Studies conducted in first-episode psychosis (FEP) patients have shown alterations in inflammation and metabolism. Our objective was to investigate potential treatment-related effects on these systems in Italian FEP patients undergoing either an experimental treatment consisting of a multi-element psychosocial intervention (EXP), including cognitive-behavioural therapy, or treatment as usual (TAU). A total of 191 FEP patients with first contact between April 2010 and March 2011 were clinically assessed at baseline and after 9 months of treatment, and the serum levels of 19 analytes were determined through single or multiplex enzyme-linked immunosorbent assays (ELISAs). A significant increase was observed in leptin levels and a significant decrease in Glucagon-Like Peptide-1 (GLP-1) levels during the treatment (time effect,

Indexed as

BiomarkersInflammationPsychotic DisordersAdolescentAdultCognitive Behavioral TherapyFemaleGhrelinGlucagon-Like Peptide 1HumansItalyLeptinMaleYoung AdultBiomarkersGhrelinGlucagon-Like Peptide 1LeptinCBTcognitive–behavioural therapyfirst-episode psychosis (FEP)ghrelinGLP-1glucagon-like peptide-1inflammationleptinmetabolismpsychosocial intervention

Identifiers

PMID41752205
PMCPMC12940655

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.