Evidence map›Paper›PMID 41752912›Full record

ReviewLife (Basel, Switzerland)2026

Kidney-Lung Crosstalk in Acute Nephrologic Involvement: Mechanisms, Complement Activation, and Implications for Multiorgan Dysfunction.

Giuliana Martino, Francesca Tinti, Marco Alfonso Perrone, Stefano Condò, Veronica Castagnola, Simone Manca de Villahermosa, Paola Triggianese, Marzena Olesinska, Alessandra Valentini, Sergio Bernardini and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giuliana MartinoNephrology and Dialysis Unit, University Hospital Tor Vergata, 00133 Rome, Italy.
Francesca TintiDepartment of Clinical and Molecular Medicine, Nephrology and Dialysis Unit, University Hospital S. Andrea, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0001-8867-3979
Marco Alfonso PerroneDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-0511-2621
Stefano CondòNephrology and Dialysis Unit, University Hospital Tor Vergata, 00133 Rome, Italy.
Veronica CastagnolaNephrology and Dialysis Unit, University Hospital Tor Vergata, 00133 Rome, Italy.
Simone Manca de VillahermosaNephrology and Dialysis Unit, University Hospital Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-3546-6604
Paola TriggianeseDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
Marzena OlesinskaDepartment of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland.ORCID 0000-0003-3028-1061
Alessandra ValentiniClinical Biochemistry Unit, University Hospital Tor Vergata, 00133 Rome, Italy.
Sergio BernardiniClinical Biochemistry Unit, University Hospital Tor Vergata, 00133 Rome, Italy.
David Della MorteDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
Ferdinando IellamoDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-8421-5065
Luca SalomoneDepartment of Clinical and Molecular Medicine, Nephrology and Dialysis Unit, University Hospital S. Andrea, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0009-0006-1929-3044
Silvia LaiDepartment of Translational and Precision Medicine, Nephrology Unit, Umberto I University Hospital, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-7199-2954
Anna Paola MitterhoferNephrology and Dialysis Unit, University Hospital Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-0132-386X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is a systemic syndrome capable of inducing remote organ dysfunction. Kidney-lung crosstalk is a form of interorgan communication in acute nephrology, with the heart acting as a pivotal intermediary. Emerging evidence supports the involvement of a gut-lung-kidney axis. Complement activation in these multiorgan crosstalk has emerged as a central amplifier of multiorgan damage. We reviewed the literature on kidney-lung interactions and complement activation in AKI through a bibliographic search of PubMed, Scopus, and Web of Science. Most available data derive from experimental studies or intensive care unit (ICU) populations, often reported in reviews. We further report our real-world experience in a non-ICU nephrology setting, including 186 consecutive patients with AKI. Pulmonary involvement was present at hospital admission in 118 patients (63%). AKI stage 1 was observed in 20/118 patients (17%) with pulmonary involvement compared with 18/68 patients (27%) without pulmonary involvement (

Indexed as

acute kidney injury (AKI)acute lung injury (ALI)C5a–C5aR1 signalingcomplement systemcomplosomeischemia–reperfusion injurykidney–lung crosstalkmultiorgan dysfunctionNETosis

Identifiers

PMID41752912
PMCPMC12941840

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.