Evidence map›Paper›PMID 41752958›Full record

ReviewLife (Basel, Switzerland)2026

Nano-Enabled Herbal Remedies for Malaria Treatment: A Review of Recent Advances.

Chang Xu, Arooj Fatima, Mahreen Fatima, Amjad Islam Aqib, Tean Zaheer, Safia Obaidur Rab, Mohd Saeed, Zeeshan Arif, Kun Li

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chang XuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Arooj FatimaDepartment of Microbiology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
Mahreen FatimaState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, College of Veterinary Medicine, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.ORCID 0009-0002-3896-7738
Amjad Islam AqibDepartment of Medicine, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.ORCID 0000-0001-7618-3948
Tean ZaheerDepartment of Entomology, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0001-8248-6451
Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61413, Saudi Arabia.
Mohd SaeedDepartment of Biology, College of Science, University of Hail, Hail 81481, Saudi Arabia.ORCID 0000-0003-3443-386X
Zeeshan ArifDepartment of Clinical Sciences, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Kun LiCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-2026-9969

Funding

Kun Li Kun Li
6 · The paper itself

Abstract

Malaria has long been a significant global health concern, listed as a high-priority disease by several global health agencies, despite of several control measures have been put in place. Most widely utilized treatment options for malaria include chloroquine, artemisinin-based combination therapy (ACT), and quinine. However, challenges, such as drug resistance, misdiagnosis, and limited treatment efficacy remain major concerns. Despite ongoing efforts, the development of an effective malaria vaccine is still debatable. Many existing malaria treatments have drawbacks, such as low water solubility, poor bioavailability, and a rise in drug-resistant parasites owing to their non-judicious use, which contributes to increased malaria cases and fatalities. Nanotechnology presents a promising approach to safer and more effective malaria therapy and control. Nanoparticles offer several advantages over conventional treatments, including high drug-loading capacity, targeted delivery, improved biocompatibility, and reduced toxicity in host cells. Green nanotechnology-based antimalarial therapies have demonstrated potential therapeutic benefits, enhanced safety, and cost-effectiveness compared to traditional treatments, ultimately improving patient compliance and treatment outcomes. In this review paper, we discussed non-conventional breakpoints in the malarial life cycle, traditional herbal remedies for malaria, and nanoparticle-based delivery systems. Additionally, we reviewed the antimalarial effects of herbal nano-formulations, their pharmacological and therapeutic potential, drug-resistant malaria, preventive strategies, vector control using green nanomaterials, and the challenges associated with plant-based nanotechnologies. This review suggests nanotechnology-based therapeutics as promising candidates to treat malaria with significant room for applications and commercialization potential in the longer run.

Indexed as

ethno-medicineherbalmalariamosquitonanotechnologyPlasmodium

Identifiers

PMID41752958
PMCPMC12941545

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.