Evidence map›Paper›PMID 41754422›Full record

ArticlePathogens (Basel, Switzerland)2026

Combinations of Favipiravir with Doxycycline, Azithromycin or Ivermectin Exert Synergistic Effects Against Influenza A H3N2 Virus Replication.

Kuan Chien Tan, Julia H Y Neo, Thai Tran, Vincent T K Chow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kuan Chien TanInfectious Diseases Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.ORCID 0009-0003-9424-2229
Julia H Y NeoInfectious Diseases Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.ORCID 0009-0007-6964-3409
Thai TranInfectious Diseases Translational Research Program, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.
Vincent T K ChowInfectious Diseases Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.ORCID 0000-0003-2634-6213

Funding

National University of Singapore E57100081601
6 · The paper itself

Abstract

Influenza A viruses constantly threaten the global population, with seasonal outbreaks occurring in different parts of the world, including avian influenza. Severe influenza A virus infections are strongly associated with the cytokine storm, which can contribute significantly to morbidity and even mortality. The virulence and high mutability of these viruses necessitate more effective treatment strategies and regimens to manage patients, especially those with a severe disease. Favipiravir is an antiviral agent approved in Japan for treating influenza virus strains resistant to the current antivirals. The objective of this study is to investigate the combination treatment of Favipiravir paired with selected repurposed drugs to determine the effectiveness of these combinations against influenza A virus replication as well as their effects on cytokine expression. Specific combinations of Favipiravir with Doxycycline, Azithromycin or Ivermectin were identified to be highly synergistic and effective in inhibiting live virus titers of an influenza H3N2 clinical strain by 4 log

Indexed as

AmidesAntiviral AgentsAzithromycinDoxycyclineInfluenza A Virus, H3N2 SubtypeIvermectinPyrazinesVirus ReplicationAnimalsCytokinesDogsDrug SynergismDrug Therapy, CombinationHumansInfluenza, HumanAmidesAntiviral AgentsAzithromycinCytokinesDoxycyclinefavipiravirIvermectinPyrazinesandrographolideartesunateazithromycincombination therapycytokine expressiondoxycyclinedrug repurposingfavipiravirinfluenza virusivermectinsynergism

Identifiers

PMID41754422
PMCPMC12943569

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.