Berberine Interferes with the Molecular Landscape of Biofilm-Driven Pathogenicity.

Anna Duda-Madej, Hanna Bazan, Jakub Łabaz, Szymon Viscardi

Abstract readReview

In one paragraph

Review in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Berberine alleviates biofilm-associated immune-inflammatory injury inFrontiers in immunology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna Duda-MadejDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 4, 50-368 Wroclaw, Poland.ORCID 0000-0001-8559-1695

Hanna BazanFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroclaw, Poland.ORCID 0009-0006-7699-5309

Jakub ŁabazFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroclaw, Poland.ORCID 0009-0007-4842-4258

Szymon ViscardiFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroclaw, Poland.ORCID 0009-0007-3668-6891

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilm-associated infections pose a significant clinical challenge due to their increased antibiotic tolerance and strong association with multidrug-resistant pathogens. The biofilm protects bacteria against antimicrobial agents and host immune response through a complex matrix, altered cell metabolism, activation of quorum sensing, and overexpression of efflux pumps. Despite the availability of numerous therapeutic strategies, the effectiveness of treatment of these infections remains limited, justifying the search for new pharmaceutics, e.g., compounds of natural origin. Berberine, an isoquinoline alkaloid from the plants of the

Indexed as

Anti-Bacterial AgentsBerberineBiofilmsGram-Negative BacteriaAnimalsBacterial AdhesionHumansQuorum SensingVirulenceAnti-Bacterial AgentsBerberineantibiofilmantimicrobial resistanceberberinebiofilmefflux pumpsmultidrug-resistantquorum sensing inhibitors

Identifiers

PMID41754445

DOI10.3390/pathogens15020194

PMCPMC12943745

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.