Evidence map›Paper›PMID 41754514›Full record

ArticleViruses2026

mRNA Vaccine Against Japanese Encephalitis Virus Genotype IV Protects Against Lethal Infection.

Abigail L Cox, Wilson Nguyen, Lucy Wales-Earl, Bing Tang, Kexin Yan, Jonathan Peters, Alexander A Khromykh, Romain Tropée, Nigel A J McMillan, Andreas Suhrbier and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abigail L CoxInfection and Inflammation Department, QIMR Berghofer, Brisbane, QLD 4029, Australia.ORCID 0000-0001-6685-3960
Wilson NguyenInfection and Inflammation Department, QIMR Berghofer, Brisbane, QLD 4029, Australia.ORCID 0000-0002-5789-4928
Lucy Wales-EarlNanomedicine Biofoundry, Institute for Biomedicine and Glycomics, Griffith University, Southport, QLD 4215, Australia.ORCID 0009-0006-9080-2024
Bing TangInfection and Inflammation Department, QIMR Berghofer, Brisbane, QLD 4029, Australia.
Kexin YanInfection and Inflammation Department, QIMR Berghofer, Brisbane, QLD 4029, Australia.
Jonathan PetersSouthern RNA Pty Ltd., 16 Nexus Way, Southport, QLD 4215, Australia.
Alexander A KhromykhSchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia.
Romain TropéeSouthern RNA Pty Ltd., 16 Nexus Way, Southport, QLD 4215, Australia.
Nigel A J McMillanNanomedicine Biofoundry, Institute for Biomedicine and Glycomics, Griffith University, Southport, QLD 4215, Australia.
Andreas SuhrbierInfection and Inflammation Department, QIMR Berghofer, Brisbane, QLD 4029, Australia.
Daniel J RawleInfection and Inflammation Department, QIMR Berghofer, Brisbane, QLD 4029, Australia.

Funding

Brazil Family Foundation Philanthropic donorMRFF (Department of Industry, Science, Energy and Resources) MRFCTI000008National Health and Medical Research Council (Australia) APP1173880National Health and Medical Research Council (Australia) APP2041411University of Queensland PhD scholarship & fee waiver
6 · The paper itself

Abstract

In 2022, Australia saw an unprecedented outbreak of Japanese encephalitis virus genotype IV (JEV GIV). The outbreak involved 42 human cases with 7 fatalities, as well as affecting >80 pig farms in New South Wales and Queensland. Herein, we designed, constructed, and tested two JEV GIV mRNA vaccines encoding prME, which provided protection against a lethal JEV GIV challenge in an

Indexed as

Encephalitis, JapaneseEncephalitis Virus, JapaneseJapanese Encephalitis VaccinesmRNA VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralDisease Models, AnimalFemaleGenotypeHumansMiceMice, KnockoutVaccinationVaccines, AttenuatedVaccines, SyntheticAntibodies, NeutralizingAntibodies, ViralJapanese Encephalitis VaccinesmRNA VaccinesVaccines, AttenuatedVaccines, Syntheticgenotype IVIfnar-/- miceJapanese encephalitis virusmRNA vaccine

Identifiers

PMID41754514
PMCPMC12945019

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.