Evidence map›Paper›PMID 41754547›Full record

ArticleViruses2026

Single-Cell Transcriptomic Profile Associated with Sub-Subtype A6 and CRF63-02A6 HIV-1 Strain Infection.

Kirill Elfimov, Anna Khozyainova, Ludmila Gotfrid, Dmitriy Baboshko, Dmitry Kapustin, Polina Achigecheva, Vasiliy Ekushov, Maksim Halikov, Mariya Gashnikova, Tatyana Bauer and 6 more

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kirill ElfimovState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0009-0002-6635-2642
Anna KhozyainovaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 634009, Russia.ORCID 0000-0002-5475-5981
Ludmila GotfridState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0000-0001-5896-8231
Dmitriy BaboshkoState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0009-0003-9052-6427
Dmitry KapustinNovosibirsk Regional Clinical Infectious Diseases Hospital, Novosibirsk 630531, Russia.ORCID 0000-0002-7060-4710
Polina AchigechevaState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0009-0006-3120-6548
Vasiliy EkushovState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0000-0002-0465-1260
Maksim HalikovState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0009-0007-1765-1909
Mariya GashnikovaState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0000-0001-9888-5422
Tatyana BauerState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0000-0002-4954-9905
Tatyana TregubchakState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0000-0001-9608-2044
Andrey MurzinState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0009-0006-8661-7109
Arina KiryakinaState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0009-0008-8246-0743
Aleksei TotmeninState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0000-0002-7418-4872
Aleksandr AgaphonovState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0000-0003-2577-0434
Natalya GashnikovaState Research Centre of Virology and Biotechnology 'Vector', Koltsovo 630559, Russia.ORCID 0000-0002-0891-0880

Funding

Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing This work was funded by the State Research and Development Program #5-21 State Research Center of Virology and Biotechnology "VECTOR".
6 · The paper itself

Abstract

We present the single-cell transcriptomic analysis of peripheral blood mononuclear cells (PBMC) from individuals during acute HIV-1 infection caused by viral strains circulating in Russia and the Former Soviet Union (FSU) countries. Using 10x Genomics single-cell RNA sequencing (scRNA-seq) on the Illumina NextSeq 550 platform, we have analyzed scRNA-seq data from three treatment-naive patients (viral load > 1 × 10

Indexed as

HIV-1HIV InfectionsSingle-Cell AnalysisTranscriptomeGene Expression ProfilingHumansLeukocytes, MononuclearSingle-Cell Gene Expression AnalysisViral Loadacute HIV infectionCRF63_02A6HIV-1immune responsesub-subtype A6transcriptomics

Identifiers

PMID41754547
PMCPMC12944885

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.