Evidence map›Paper›PMID 41754582›Full record

SynthesisViruses2026

Effect of Direct-Acting Antiviral Therapy on Glycemic Control in Patients with Chronic Hepatitis C and Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Jing-Hong Hu, Ming-Ling Chang, Ming-Shyan Lin, Tung-Jung Huang, Yung-Yu Hsieh

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing-Hong HuDivision of Gastroenterology and Hepatology, Yunlin Chang Gung Memorial Hospital, Yunlin 638, Taiwan.ORCID 0000-0002-1514-9575
Ming-Ling ChangDivision of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0003-4902-4401
Ming-Shyan LinDivision of Cardiology, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan.ORCID 0000-0001-9348-8153
Tung-Jung HuangDepartment of Internal Medicine, Yunlin Chang Gung Memorial Hospital, Yunlin 638, Taiwan.
Yung-Yu HsiehDivision of Gastroenterology, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan.ORCID 0000-0001-8465-5204

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The eradication of hepatitis C virus (HCV) with interferon-free direct-acting antivirals (DAAs) has transformed the management of chronic HCV infection. Chronic HCV infection is associated with an increased risk of type 2 diabetes mellitus (T2DM) and poor glycemic control. However, the magnitude and consistency of improvement in glycated hemoglobin (HbA1c) after DAA-induced sustained virologic response (SVR) in patients with established T2DM remain unclear. We conducted a systematic review and meta-analysis of six cohort studies comprising 2805 patients. Overall, DAA therapy was associated with a significant reduction in HbA1c after SVR, with a pooled random-effect mean difference of -0.45% (95% CI -0.74% to -0.16%; I

Indexed as

Antiviral AgentsDiabetes Mellitus, Type 2Glycemic ControlHepatitis C, ChronicBlood GlucoseGlycated HemoglobinHepacivirusHumansSustained Virologic ResponseAntiviral AgentsBlood GlucoseGlycated Hemoglobindirect-acting antiviralsglycemic controlHbA1chepatitis Cmeta-analysistype 2 diabetes mellitus

Identifiers

PMID41754582
PMCPMC12945286

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.