Fetal and Neonatal Immune Response to Congenital Cytomegalovirus (cCMV) Infection: A Systematically Conducted Scoping Review.

Chrysanthi-Eleni Loizou, Antonios Gkantaras, Sofia Karagiannidou, Garyfallia Syridou, Despoina Gkentzi, Vassiliki Papaevangelou, Evangelia Farmaki

Abstract readScoping Review

PubMed Full text at PMC Publisher

In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chrysanthi-Eleni LoizouThird Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, University General Hospital "Attikon", 124 62 Athens, Greece.ORCID 0000-0001-8143-2240

Antonios GkantarasFirst Department of Pediatrics, Pediatric Immunology and Rhumatology Referral Center, Aristotle University of Thessaloniki, "Hippokration" General Hospital, 546 42 Thessaloniki, Greece.ORCID 0000-0003-3609-1824

Sofia KaragiannidouThird Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, University General Hospital "Attikon", 124 62 Athens, Greece.

Garyfallia SyridouThird Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, University General Hospital "Attikon", 124 62 Athens, Greece.

Despoina GkentziDepartment of Pediatrics, Patras Medical School, University General Hospital of Patras, 265 04 Rio, Greece.ORCID 0000-0002-1421-0813

Vassiliki PapaevangelouThird Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, University General Hospital "Attikon", 124 62 Athens, Greece.ORCID 0000-0001-6075-3002

Evangelia FarmakiFirst Department of Pediatrics, Pediatric Immunology and Rhumatology Referral Center, Aristotle University of Thessaloniki, "Hippokration" General Hospital, 546 42 Thessaloniki, Greece.ORCID 0000-0002-5132-8255

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital Cytomegalovirus (cCMV) infection is associated with numerous long-term sequelae. This scoping review consolidates existing evidence on fetal and neonatal immune response to cCMV and their potential relevance to clinical outcomes. A systematic search was conducted in the PubMed database. Observational studies were eligible when full text was available in English and data for immune response (innate, humoral, cellular) and/or immune-related biomarkers (cytokines and molecular markers) were provided. Thirty-four studies were included. CMV-infected fetuses mount robust γδ and CD8

Indexed as

CytomegalovirusCytomegalovirus InfectionsFetusCD8-Positive T-LymphocytesCytokinesFemaleHumansInfant, NewbornPregnancyPregnancy Complications, InfectiousCytokineschemokinescongenital Cytomegaloviruscytokinesimmune responseNK cellsT cell exhaustionT cellstranscriptomic signatures

Identifiers

PMID41754585

DOI10.3390/v18020242

PMCPMC12945067

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.