Evidence map›Paper›PMID 41754587›Full record

ReviewViruses2026

Hepatitis D Virus: Enigmas and Gaps of Knowledge.

Flor H Pujol, Rossana Celeste Jaspe, Armando Andres Roca Suarez, Enkhtuul Batbold, Fabien Zoulim, Barbara Testoni, Isabelle Chemin

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Flor H PujolLaboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas 1020A, Venezuela.ORCID 0000-0001-6086-6883
Rossana Celeste JaspeLaboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas 1020A, Venezuela.ORCID 0000-0002-4816-1378
Armando Andres Roca SuarezINSERM Unité Mixte de Recherche 1350, PaThLiv IHU EVEREST, Université Claude-Bernard Lyon 1, 69003 Lyon, France.ORCID 0000-0002-2245-3831
Enkhtuul BatboldINSERM Unité Mixte de Recherche 1350, PaThLiv IHU EVEREST, Université Claude-Bernard Lyon 1, 69003 Lyon, France.
Fabien ZoulimINSERM Unité Mixte de Recherche 1350, PaThLiv IHU EVEREST, Université Claude-Bernard Lyon 1, 69003 Lyon, France.ORCID 0000-0002-2245-0083
Barbara TestoniINSERM Unité Mixte de Recherche 1350, PaThLiv IHU EVEREST, Université Claude-Bernard Lyon 1, 69003 Lyon, France.ORCID 0000-0001-5588-5465
Isabelle CheminINSERM Unité Mixte de Recherche 1350, PaThLiv IHU EVEREST, Université Claude-Bernard Lyon 1, 69003 Lyon, France.ORCID 0000-0002-7188-5489

Funding

Agence Nationale de la Recherche ANR-23-IAHU-0008)Agence Nationale de Recherches sur le Sida et les Hépatites Virales ANRS ECTZ289707, ECTZ206376, ECTZ330639
6 · The paper itself

Abstract

Hepatitis D virus (HDV) is a very peculiar virus that shares many characteristics with plant viroids. One of its unique characteristics is the requirement for the presence of a helper virus for its replication, and in particular enveloping its virion, a role often played by the hepatitis B virus (HBV). Infection with HDV is frequently associated with more severe disease, which may present with fulminant hepatitis or a more rapid progression to cirrhosis and hepatocellular carcinoma (HCC), when compared to HBV mono-infection. HDV exhibits many peculiarities and enigmas, which have led to it being considered a neglected virus. This review aims to identify the most important gaps in knowledge and peculiarities in the study of this enigmatic virus, from virology to clinical implications.

Indexed as

Hepatitis DHepatitis Delta VirusAnimalsCarcinoma, HepatocellularHepatitis B virusHumansLiver NeoplasmsVirus ReplicationDeltaviruseradicationhepatitis D virushepatocellular carcinomareplication

Identifiers

PMID41754587
PMCPMC12944862

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.