Evidence mapPaperPMID 41754590Full record

ReviewViruses2026

SARS-CoV-2 Persistence and the Gut Microbiota: New Insights into Long COVID Pathogenesis.

Sofia De Stefanis, Francesca Colavita, Fabrizio Maggi, Manuela Antonioli

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sofia De StefanisPh.D. Program in Cellular and Molecular Biology, Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Francesca ColavitaLaboratory of Virology and Laboratories of Biosafety, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0003-0640-8667
Fabrizio MaggiLaboratory of Virology and Laboratories of Biosafety, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7489-5271
Manuela AntonioliDepartment of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0002-7568-4713

Funding

Ministero della Salute Ricerca Corrente Linea 1 - Progetto 1 to IRCCS INMI L. SpallanzaniUniversity of Rome Tor Vergata Ricerca di Ateneo 2024- Dipartimento di Biologia (AutoCuRC)
6 · The paper itself

Abstract

In December 2019, the world experienced the emergence of a new virus, SARS-CoV-2, which caused the 2020 pandemic. SARS-CoV-2 causes COVID-19, primarily affecting the respiratory system, as well as the gastrointestinal tract. Remarkably, one in eight COVID-19 patients develops Long COVID, which is linked to SARS-CoV-2 persistence in the gastrointestinal tract, resulting in chronic inflammation and microbiota dysregulation. Given that gut microbiota dysbiosis plays a pivotal role in antiviral defense and gastrointestinal conditions, here we examine emerging evidence on how persistent SARS-CoV-2 infection may contribute to the aetiology of enteric disorders. In particular, we emphasise the intricate connection between chronic inflammation caused by persistent SARS-CoV-2 infection (e.g., irritable bowel syndrome and inflammatory bowel disease) and the possible development of diseases such as Crohn's disease and ulcerative colitis.

Indexed as

COVID-19Gastrointestinal MicrobiomeDysbiosisGastrointestinal TractHumansInflammationInflammatory Bowel DiseasesPandemicsPost-Acute COVID-19 SyndromeSARS-CoV-2gut microbiotaLong COVIDSARS-CoV-2

Identifiers

PMID41754590
PMCPMC12945300

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.