Evidence map›Paper›PMID 41754821›Full record

ArticlePharmaceuticals (Basel, Switzerland)2026

Simufilam in Alzheimer's Disease: Assessment of Efficacy of a Controversial Drug in Human Neuronal Cell Culture.

Ankita Srivastava, Heather A Renna, Tahmina Hossain, Thomas Palaia, Aaron Pinkhasov, Irving H Gomolin, Joshua De Leon, Thomas Wisniewski, Allison B Reiss

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ankita SrivastavaDepartment of Foundations of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.ORCID 0000-0001-7872-2183
Heather A RennaDepartment of Foundations of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Tahmina HossainDepartment of Foundations of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Thomas PalaiaDepartment of Foundations of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.ORCID 0000-0002-4568-4296
Aaron PinkhasovDepartment of Psychiatry, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.ORCID 0000-0002-1148-902X
Irving H GomolinDepartment of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Joshua De LeonDepartment of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Thomas WisniewskiDepartments of Neurology, Pathology and Psychiatry, Center for Cognitive Neurology, Grossman School of Medicine, New York University, New York, NY 10016, USA.ORCID 0000-0002-3379-8966
Allison B ReissDepartment of Foundations of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.ORCID 0000-0002-4478-2441

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
Multi-scale and multi-modality imaging of neuropathology in VCIDU24NS135568 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JAMES C GEE, Yulin Ge · 2023 to 2026
$6.6M
ARIA Pathophysiology Characterized by in vivo Neuroimaging, Plasma Biomarkers and Post-Mortem ProteomicsU24NS141774 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GE, YULIN, LU, HANZHANG · 2025 to 2025
$3.3M
Alzheimer's Foundation of America AWD00004772NIH HHS P30AG066512NIH HHS U24NS135568NIH HHS U24 NS141774The Herb and Evelyn Abrams Family Amyloid Research Fund 01
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer’s diseaseamyloid betaelectron microscopyin vitro modelmitochondrianeurodegenerative diseaseneuronpathophysiology

Identifiers

PMID41754821
PMCPMC12944517

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.